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- NCIT_C180524 IAO_0000115 "A preparation of allogeneic, human leukocyte antigen (HLA) matched, cluster of differentiation 34 (CD34)-positive human hematopoietic stem and progenitor cells (HSPCs) that are ex-vivo gene-edited with the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nuclease complex to remove the cluster of differentiation 33 (CD33) antigen, that can potentially be used to improve hematopoietic recovery after hematopoietic cell transplantation (HCT) and CD33-targeting chemotherapy. Upon administration, tremtelectogene empogeditemcel increases and restores the number of HSPCs, which may prevent or decrease infection and other complications of HCT and chemotherapy-induced neutropenia (CIN). The removal of CD33 protects VOR33 from the cytotoxic effects of CD33-targeted agents administered after HCT." @default.
- NCIT_C180524 NCIT_NHC0 "C180524" @default.
- NCIT_C180524 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C180524 NCIT_P107 "Tremtelectogene Empogeditemcel" @default.
- NCIT_C180524 NCIT_P108 "Tremtelectogene Empogeditemcel" @default.
- NCIT_C180524 NCIT_P208 "CL1663066" @default.
- NCIT_C180524 NCIT_P319 "CT5FM8JN3S" @default.
- NCIT_C180524 NCIT_P322 "CTRP" @default.
- NCIT_C180524 NCIT_P322 "FDA" @default.
- NCIT_C180524 NCIT_P399 "805163" @default.
- NCIT_C180524 normalizedInformationContent "100" @default.
- NCIT_C180524 referenceCount "1" @default.
- NCIT_C180524 hasExactSynonym "Allogeneic CRISPR/Cas9-edited CD33-depleted CD34-positive HSCs VOR33" @default.
- NCIT_C180524 hasExactSynonym "Allogeneic CRISPR/Cas9-edited CD33-depleted CD34-positive HSPCs VOR33" @default.
- NCIT_C180524 hasExactSynonym "Allogeneic CRISPR/Cas9-edited CD33-depleted CD34-positive Hematopoietic Stem and Progenitor Cells VOR33" @default.
- NCIT_C180524 hasExactSynonym "TREMTELECTOGENE EMPOGEDITEMCEL" @default.
- NCIT_C180524 hasExactSynonym "Trem-cel" @default.
- NCIT_C180524 hasExactSynonym "Tremtelectogene Empogeditemcel" @default.
- NCIT_C180524 hasExactSynonym "VOR 33" @default.
- NCIT_C180524 hasExactSynonym "VOR-33" @default.
- NCIT_C180524 hasExactSynonym "VOR33" @default.
- NCIT_C180524 hasExactSynonym "eHSCs VOR33" @default.
- NCIT_C180524 inSubset NCIT_C116977 @default.
- NCIT_C180524 inSubset NCIT_C116978 @default.
- NCIT_C180524 inSubset NCIT_C176424 @default.
- NCIT_C180524 inSubset NCIT_C63923 @default.
- NCIT_C180524 type Class @default.
- NCIT_C180524 isDefinedBy ncit.owl @default.
- NCIT_C180524 label "Tremtelectogene Empogeditemcel" @default.
- NCIT_C180524 subClassOf NCIT_C142078 @default.
- NCIT_C180524 subClassOf NCIT_C180524 @default.
- NCIT_C180524 subClassOf NCIT_C1908 @default.
- NCIT_C180524 subClassOf NCIT_C1909 @default.
- NCIT_C180524 subClassOf NCIT_C201554 @default.
- NCIT_C180524 subClassOf NCIT_C307 @default.
- NCIT_C180524 subClassOf NCIT_C308 @default.