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- NCIT_C180533 IAO_0000115 "A fixed dose combination of empagliflozin, an inhibitor of sodium-glucose co-transporter 2 (SGLT2; SLC5A2), and linagliptin, a dihydropurinedione-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with antihyperglycemic activity. Upon oral administration of empagliflozin/linagliptin, empagliflozin selectively and potently inhibits SGLT2 in the kidneys, thereby suppressing the reabsorption of glucose in the proximal tubule. Inhibition of SGLT2 increases urinary glucose excretion by the kidneys, resulting in a reduction of plasma glucose levels in an insulin-independent manner. Linagliptin binds to and inhibits DPP-4, thereby inhibiting the breakdown of the incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). This prolongs the activity of these incretin hormones, increases postprandial insulin secretion from pancreatic beta cells, decreases glucagon secretion and lowers blood glucose levels. SGLT2, a transport protein exclusively expressed in the proximal renal tubules, mediates approximately 90% of renal glucose reabsorption from tubular fluid. DPP-4 is a serine protease that degrades the incretin hormones GLP-1 and GIP, which play important roles in the regulation of glucose homeostasis." @default.
- NCIT_C180533 NCIT_NHC0 "C180533" @default.
- NCIT_C180533 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C180533 NCIT_P108 "Empagliflozin/Linagliptin" @default.
- NCIT_C180533 NCIT_P208 "CL1663053" @default.
- NCIT_C180533 normalizedInformationContent "100" @default.
- NCIT_C180533 referenceCount "1" @default.
- NCIT_C180533 hasExactSynonym "Empagliflozin and Linagliptin" @default.
- NCIT_C180533 hasExactSynonym "Empagliflozin-Linagliptin" @default.
- NCIT_C180533 hasExactSynonym "Empagliflozin/Linagliptin Combination Agent" @default.
- NCIT_C180533 hasExactSynonym "Empagliflozin/Linagliptin" @default.
- NCIT_C180533 hasExactSynonym "Glyxambi" @default.
- NCIT_C180533 type Class @default.
- NCIT_C180533 isDefinedBy ncit.owl @default.
- NCIT_C180533 label "Empagliflozin/Linagliptin" @default.
- NCIT_C180533 subClassOf NCIT_C180533 @default.
- NCIT_C180533 subClassOf NCIT_C1908 @default.
- NCIT_C180533 subClassOf NCIT_C1909 @default.
- NCIT_C180533 subClassOf NCIT_C29711 @default.
- NCIT_C180533 subClassOf NCIT_C471 @default.
- NCIT_C180533 subClassOf NCIT_C78276 @default.
- NCIT_C180533 subClassOf NCIT_C783 @default.
- NCIT_C180533 subClassOf NCIT_C98083 @default.
- NCIT_C180533 subClassOf NCIT_C98086 @default.