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- NCIT_C180535 IAO_0000115 "An orally available selective inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity. Upon administration, alflutinib specifically binds to and inhibits the tyrosine kinase activity of EGFR T790M, a secondarily acquired resistance mutation. This prevents EGFR T790M-mediated signaling and leads to cell death in EGFR T790M-expressing tumor cells. EGFR, a receptor tyrosine kinase that is mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization. Compared to some other EGFR inhibitors, alflutinib may have therapeutic benefits in tumors with T790M-mediated drug resistance." @default.
- NCIT_C180535 NCIT_A5 NCIT_C133719 @default.
- NCIT_C180535 NCIT_A7 NCIT_C98503 @default.
- NCIT_C180535 NCIT_NHC0 "C180535" @default.
- NCIT_C180535 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C180535 NCIT_P108 "Alflutinib" @default.
- NCIT_C180535 NCIT_P208 "CL1663055" @default.
- NCIT_C180535 NCIT_P210 "1869057-83-9" @default.
- NCIT_C180535 NCIT_P319 "A49A7A5YN4" @default.
- NCIT_C180535 NCIT_P322 "FDA" @default.
- NCIT_C180535 normalizedInformationContent "100" @default.
- NCIT_C180535 referenceCount "1" @default.
- NCIT_C180535 hasExactSynonym "2-Propenamide, N-(2-((2-(dimethylamino)ethyl)methylamino)-5-((4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl)amino)-6-(2,2,2-trifluoroethoxy)-3-pyridinyl)-" @default.
- NCIT_C180535 hasExactSynonym "AST 2818" @default.
- NCIT_C180535 hasExactSynonym "AST-2818" @default.
- NCIT_C180535 hasExactSynonym "AST2818" @default.
- NCIT_C180535 hasExactSynonym "Alflutinib" @default.
- NCIT_C180535 hasExactSynonym "FURMONERTINIB" @default.
- NCIT_C180535 hasExactSynonym "Furmonertinib" @default.
- NCIT_C180535 inSubset NCIT_C128784 @default.
- NCIT_C180535 inSubset NCIT_C63923 @default.
- NCIT_C180535 type Class @default.
- NCIT_C180535 isDefinedBy ncit.owl @default.
- NCIT_C180535 label "Alflutinib" @default.
- NCIT_C180535 subClassOf NCIT_C129824 @default.
- NCIT_C180535 subClassOf NCIT_C129825 @default.
- NCIT_C180535 subClassOf NCIT_C1404 @default.
- NCIT_C180535 subClassOf NCIT_C163758 @default.
- NCIT_C180535 subClassOf NCIT_C163952 @default.
- NCIT_C180535 subClassOf NCIT_C180535 @default.
- NCIT_C180535 subClassOf NCIT_C1908 @default.
- NCIT_C180535 subClassOf NCIT_C1909 @default.
- NCIT_C180535 subClassOf NCIT_C1967 @default.
- NCIT_C180535 subClassOf NCIT_C2167 @default.
- NCIT_C180535 subClassOf NCIT_C2189 @default.
- NCIT_C180535 subClassOf NCIT_C274 @default.
- NCIT_C180535 subClassOf NCIT_C471 @default.