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- NCIT_C18054 IAO_0000115 "Neurogenic locus notch homolog protein 4 (2003 aa, ~210 kDa) is encoded by the human NOTCH4 gene. This protein plays a role in both cell-fate determination and cell-cell signaling." @default.
- NCIT_C18054 NCIT_NHC0 "C18054" @default.
- NCIT_C18054 NCIT_P100 "164951" @default.
- NCIT_C18054 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C18054 NCIT_P106 "Receptor" @default.
- NCIT_C18054 NCIT_P107 "Neurogenic Locus Notch Homolog Protein 4" @default.
- NCIT_C18054 NCIT_P108 "Neurogenic Locus Notch Homolog Protein 4" @default.
- NCIT_C18054 NCIT_P207 "C0539211" @default.
- NCIT_C18054 NCIT_P322 "CTRP" @default.
- NCIT_C18054 NCIT_P366 "Notch4_Protein" @default.
- NCIT_C18054 NCIT_P93 "Q99466" @default.
- NCIT_C18054 NCIT_P98 "Neurogenic locus notch homolog protein 4 has 29 extracellular EGF-like repeats, three Notch/lin-12 repeats, a transmembrane region, six intracellular cdc10/ankyrin repeats, a polyglutamine domain, and a C-terminal PEST region. A component of an evolutionarily conserved intercellular signaling mechanism, NOTCH4 is expressed in a variety of tissues and appears to regulate cell fate decisions during embryonic vascular morphogenesis and remodeling. NOTCH4 and NOTCH1 appear to have partially overlapping roles during embryogenesis in mice. MMTV INT3 interruption of NOTCH4 produces a gain-of-function truncated product, containing only the transmembrane and intracellular domains, that has profound consequences for mammary gland development and tumorigenesis. (OMIM)" @default.
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- NCIT_C18054 hasExactSynonym "Human Homolog 4 of Drosophila Notch4 Protein" @default.
- NCIT_C18054 hasExactSynonym "NOTCH4" @default.
- NCIT_C18054 hasExactSynonym "Neurogenic Locus Notch Homolog Protein 4 Notch Homolog 4" @default.
- NCIT_C18054 hasExactSynonym "Neurogenic Locus Notch Homolog Protein 4" @default.
- NCIT_C18054 hasExactSynonym "Notch 4" @default.
- NCIT_C18054 hasExactSynonym "Notch4 / Int3 Gene Product" @default.
- NCIT_C18054 hasExactSynonym "hNotch4" @default.
- NCIT_C18054 inSubset NCIT_C116977 @default.
- NCIT_C18054 inSubset NCIT_C142799 @default.
- NCIT_C18054 inSubset NCIT_C142800 @default.
- NCIT_C18054 type Class @default.
- NCIT_C18054 isDefinedBy ncit.owl @default.
- NCIT_C18054 label "Neurogenic Locus Notch Homolog Protein 4" @default.
- NCIT_C18054 subClassOf NCIT_C17021 @default.
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