Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C180570> ?p ?o ?g. }
Showing items 1 to 37 of
37
with 100 items per page.
- NCIT_C180570 IAO_0000115 "A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19 and containing a short hairpin RNA (shRNA) against the pro-inflammatory cytokine interleukin-6 (IL-6), and linked to the intracellular signaling domains of 4-1BB (CD137) and the zeta chain of the TCR/CD3 complex (TCRzeta; CD247; CD3zeta), with potential immunostimulating and antineoplastic activities. Upon administration, short hairpin RNA-IL-6 gene silencing anti-CD19 CAR T cells target and bind to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. IL-6 gene silencing reduces IL-6 gene expression and release. This may inhibit IL-6-mediated toxicity due to high IL-6 levels and may prevent severe cytokine release syndrome (CRS) and CAR-T-related encephalopathy (CRES)." @default.
- NCIT_C180570 NCIT_A7 NCIT_C38894 @default.
- NCIT_C180570 NCIT_NHC0 "C180570" @default.
- NCIT_C180570 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C180570 NCIT_P108 "Short Hairpin RNA-IL-6 Gene Silencing Anti-CD19 CAR T Cells" @default.
- NCIT_C180570 NCIT_P208 "CL1662959" @default.
- NCIT_C180570 NCIT_P322 "GDC" @default.
- NCIT_C180570 NCIT_P399 "805495" @default.
- NCIT_C180570 normalizedInformationContent "100" @default.
- NCIT_C180570 referenceCount "1" @default.
- NCIT_C180570 hasExactSynonym "Anti-CD19-CAR-Ts with shRNA-IL-6 Gene Silencing" @default.
- NCIT_C180570 hasExactSynonym "Short Hairpin RNA-IL-6 Gene Silencing Anti-CD19 CAR T Cells" @default.
- NCIT_C180570 hasExactSynonym "Short Hairpin RNA-IL-6-modified Anti-CD19 CAR-T Cells" @default.
- NCIT_C180570 hasExactSynonym "shRNA-IL-6 Gene Silencing Anti-CD19 CAR T Cells" @default.
- NCIT_C180570 hasExactSynonym "shRNA-IL-6-modified Anti-CD19 CAR-T Cells" @default.
- NCIT_C180570 hasExactSynonym "ssCART-19 Cells" @default.
- NCIT_C180570 inSubset NCIT_C128784 @default.
- NCIT_C180570 inSubset NCIT_C157711 @default.
- NCIT_C180570 inSubset NCIT_C157712 @default.
- NCIT_C180570 inSubset NCIT_C176424 @default.
- NCIT_C180570 type Class @default.
- NCIT_C180570 isDefinedBy ncit.owl @default.
- NCIT_C180570 label "Short Hairpin RNA-IL-6 Gene Silencing Anti-CD19 CAR T Cells" @default.
- NCIT_C180570 subClassOf NCIT_C129820 @default.
- NCIT_C180570 subClassOf NCIT_C129821 @default.
- NCIT_C180570 subClassOf NCIT_C129826 @default.
- NCIT_C180570 subClassOf NCIT_C137999 @default.
- NCIT_C180570 subClassOf NCIT_C142078 @default.
- NCIT_C180570 subClassOf NCIT_C154231 @default.
- NCIT_C180570 subClassOf NCIT_C176018 @default.
- NCIT_C180570 subClassOf NCIT_C180570 @default.
- NCIT_C180570 subClassOf NCIT_C1908 @default.
- NCIT_C180570 subClassOf NCIT_C1909 @default.
- NCIT_C180570 subClassOf NCIT_C1962 @default.
- NCIT_C180570 subClassOf NCIT_C274 @default.
- NCIT_C180570 subClassOf NCIT_C307 @default.
- NCIT_C180570 subClassOf NCIT_C308 @default.