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- NCIT_C180583 IAO_0000115 "The hemifumarate salt form of HC-5404, an orally bioavailable inhibitor of the serine/threonine kinase protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK; eukaryotic translation initiation factor 2-alpha kinase 3; EIF2AK3; PEK) with potential antineoplastic activity. Upon oral administration of PERK inhibitor HC-5404-FU, HC-5404 inhibits the activity of PERK. This prevents the activation of the PERK pathway and inhibits unfolded protein response (UPR) stress adaptation, which may lead to tumor cell apoptosis and the inhibition of tumor growth. PERK, one of the key sensors for the UPR, plays a key role in the response to and resolution of endoplasmic reticulum (ER) stress and also in tumor angiogenesis and survival." @default.
- NCIT_C180583 NCIT_A7 NCIT_C102829 @default.
- NCIT_C180583 NCIT_NHC0 "C180583" @default.
- NCIT_C180583 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C180583 NCIT_P107 "PERK Inhibitor HC-5404-FU" @default.
- NCIT_C180583 NCIT_P108 "PERK Inhibitor HC-5404-FU" @default.
- NCIT_C180583 NCIT_P208 "CL1662953" @default.
- NCIT_C180583 NCIT_P322 "CTRP" @default.
- NCIT_C180583 NCIT_P322 "GDC" @default.
- NCIT_C180583 NCIT_P399 "805511" @default.
- NCIT_C180583 normalizedInformationContent "100" @default.
- NCIT_C180583 referenceCount "1" @default.
- NCIT_C180583 hasExactSynonym "HC 5404 Hemifumarate" @default.
- NCIT_C180583 hasExactSynonym "HC 5404-FU" @default.
- NCIT_C180583 hasExactSynonym "HC-5404 FU" @default.
- NCIT_C180583 hasExactSynonym "HC-5404-FU" @default.
- NCIT_C180583 hasExactSynonym "HC5404-FU" @default.
- NCIT_C180583 hasExactSynonym "PERK Inhibitor HC-5404-FU" @default.
- NCIT_C180583 hasExactSynonym "PERKi HC 5404-FU" @default.
- NCIT_C180583 inSubset NCIT_C116977 @default.
- NCIT_C180583 inSubset NCIT_C116978 @default.
- NCIT_C180583 inSubset NCIT_C128784 @default.
- NCIT_C180583 inSubset NCIT_C157711 @default.
- NCIT_C180583 inSubset NCIT_C157712 @default.
- NCIT_C180583 inSubset NCIT_C176424 @default.
- NCIT_C180583 type Class @default.
- NCIT_C180583 isDefinedBy ncit.owl @default.
- NCIT_C180583 label "PERK Inhibitor HC-5404-FU" @default.
- NCIT_C180583 subClassOf NCIT_C129824 @default.
- NCIT_C180583 subClassOf NCIT_C129825 @default.
- NCIT_C180583 subClassOf NCIT_C180583 @default.
- NCIT_C180583 subClassOf NCIT_C1908 @default.
- NCIT_C180583 subClassOf NCIT_C1909 @default.
- NCIT_C180583 subClassOf NCIT_C2189 @default.
- NCIT_C180583 subClassOf NCIT_C274 @default.
- NCIT_C180583 subClassOf NCIT_C471 @default.