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- NCIT_C180585 IAO_0000115 "An antibody-drug conjugate (ADC) consisting of a human immunoglobulin G1 (IgG1) monoclonal antibody directed against the epidermal growth factor receptor (EGFR) conjugated to monomethyl auristatin E (MMAE), an auristatin derivative and potent microtubule disrupting agent, with potential antineoplastic activity. Upon administration of anti-EGFR ADC MRG003, the monoclonal antibody moiety binds to EGFR on tumor cell surfaces. Following receptor internalization, the MMAE moiety is released and binds to tubulin and inhibits its polymerization, which results in G2/M phase arrest and apoptosis. This inhibits the proliferation of EGFR-expressing tumor cells. EGFR, overexpressed by a variety of cancers, plays a key role in tumor cell proliferation and survival." @default.
- NCIT_C180585 NCIT_A7 NCIT_C17068 @default.
- NCIT_C180585 NCIT_NHC0 "C180585" @default.
- NCIT_C180585 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C180585 NCIT_P108 "Anti-EGFR Antibody-drug Conjugate MRG003" @default.
- NCIT_C180585 NCIT_P208 "CL1662947" @default.
- NCIT_C180585 NCIT_P322 "GDC" @default.
- NCIT_C180585 NCIT_P399 "805513" @default.
- NCIT_C180585 normalizedInformationContent "100" @default.
- NCIT_C180585 referenceCount "1" @default.
- NCIT_C180585 hasExactSynonym "Anti-EGFR ADC MRG003" @default.
- NCIT_C180585 hasExactSynonym "Anti-EGFR Antibody-drug Conjugate MRG003" @default.
- NCIT_C180585 hasExactSynonym "Anti-EGFR/MMAE Antibody-drug Conjugate MRG003" @default.
- NCIT_C180585 hasExactSynonym "MRG 003" @default.
- NCIT_C180585 hasExactSynonym "MRG-003" @default.
- NCIT_C180585 hasExactSynonym "MRG003" @default.
- NCIT_C180585 inSubset NCIT_C128784 @default.
- NCIT_C180585 inSubset NCIT_C157711 @default.
- NCIT_C180585 inSubset NCIT_C157712 @default.
- NCIT_C180585 inSubset NCIT_C176424 @default.
- NCIT_C180585 type Class @default.
- NCIT_C180585 isDefinedBy ncit.owl @default.
- NCIT_C180585 label "Anti-EGFR Antibody-drug Conjugate MRG003" @default.
- NCIT_C180585 subClassOf NCIT_C129821 @default.
- NCIT_C180585 subClassOf NCIT_C129823 @default.
- NCIT_C180585 subClassOf NCIT_C1512 @default.
- NCIT_C180585 subClassOf NCIT_C163758 @default.
- NCIT_C180585 subClassOf NCIT_C163952 @default.
- NCIT_C180585 subClassOf NCIT_C180585 @default.
- NCIT_C180585 subClassOf NCIT_C1908 @default.
- NCIT_C180585 subClassOf NCIT_C1909 @default.
- NCIT_C180585 subClassOf NCIT_C201551 @default.
- NCIT_C180585 subClassOf NCIT_C274 @default.
- NCIT_C180585 subClassOf NCIT_C307 @default.
- NCIT_C180585 subClassOf NCIT_C308 @default.