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- NCIT_C180589 IAO_0000115 "An antibody-drug conjugate (ADC) comprised of a monoclonal antibody against human tissue factor (TF) conjugated, via a protease-cleavable BCN-valyl-citrulline linker, with monomethyl auristatin E (MMAE), an auristatin derivative and potent microtubule disrupting agent, with potential antiangiogenic, anticoagulant and antineoplastic activities. Upon administration of anti-TF ADC MRG004A, the monoclonal antibody moiety binds to cell surface TF and is internalized. After internalization of the agent, the MMAE moiety is released by proteolytic cleavage. It then binds to tubulin and inhibits its polymerization, which results in G2/M phase arrest and apoptosis. TF, a transmembrane protein and initiator of the coagulation cascade, is overexpressed in many tumor cells and tumor-resident endothelial cells. Expression of TF is correlated with metastasis, angiogenesis, tumor cell growth and tumor-associated thrombosis." @default.
- NCIT_C180589 NCIT_A7 NCIT_C17197 @default.
- NCIT_C180589 NCIT_NHC0 "C180589" @default.
- NCIT_C180589 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C180589 NCIT_P108 "Anti-TF Antibody-drug Conjugate MRG004A" @default.
- NCIT_C180589 NCIT_P208 "CL1662928" @default.
- NCIT_C180589 NCIT_P322 "GDC" @default.
- NCIT_C180589 NCIT_P399 "805525" @default.
- NCIT_C180589 normalizedInformationContent "100" @default.
- NCIT_C180589 referenceCount "1" @default.
- NCIT_C180589 hasExactSynonym "Anti-TF ADC MRG004A" @default.
- NCIT_C180589 hasExactSynonym "Anti-TF Antibody-drug Conjugate MRG004A" @default.
- NCIT_C180589 hasExactSynonym "MRG 004A" @default.
- NCIT_C180589 hasExactSynonym "MRG-004A" @default.
- NCIT_C180589 hasExactSynonym "MRG004A" @default.
- NCIT_C180589 inSubset NCIT_C128784 @default.
- NCIT_C180589 inSubset NCIT_C157711 @default.
- NCIT_C180589 inSubset NCIT_C157712 @default.
- NCIT_C180589 inSubset NCIT_C176424 @default.
- NCIT_C180589 type Class @default.
- NCIT_C180589 isDefinedBy ncit.owl @default.
- NCIT_C180589 label "Anti-TF Antibody-drug Conjugate MRG004A" @default.
- NCIT_C180589 subClassOf NCIT_C129821 @default.
- NCIT_C180589 subClassOf NCIT_C129823 @default.
- NCIT_C180589 subClassOf NCIT_C1512 @default.
- NCIT_C180589 subClassOf NCIT_C180589 @default.
- NCIT_C180589 subClassOf NCIT_C1908 @default.
- NCIT_C180589 subClassOf NCIT_C1909 @default.
- NCIT_C180589 subClassOf NCIT_C274 @default.
- NCIT_C180589 subClassOf NCIT_C307 @default.
- NCIT_C180589 subClassOf NCIT_C308 @default.