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- NCIT_C180591 IAO_0000115 "A long-acting depot formulation of a gonadotropin-releasing hormone (GnRH) receptor antagonist decapeptide, with potential hormone production inhibitory activity. Upon subcutaneous administration, GnRH antagonist VERU-100 competes with GnRH for receptor binding and inhibits GnRH receptor signaling in the anterior pituitary gland, thereby inhibiting the secretion and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH). In males, the inhibition of LH secretion prevents the release of testosterone. As a result, this may relieve symptoms associated with hormonally dependent disease states such as hormone-dependent prostate cancer." @default.
- NCIT_C180591 NCIT_A7 NCIT_C38910 @default.
- NCIT_C180591 NCIT_NHC0 "C180591" @default.
- NCIT_C180591 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C180591 NCIT_P108 "GnRH Antagonist VERU-100" @default.
- NCIT_C180591 NCIT_P208 "CL1662930" @default.
- NCIT_C180591 NCIT_P322 "GDC" @default.
- NCIT_C180591 NCIT_P399 "805527" @default.
- NCIT_C180591 normalizedInformationContent "100" @default.
- NCIT_C180591 referenceCount "1" @default.
- NCIT_C180591 hasExactSynonym "GnRH Antagonist VERU-100" @default.
- NCIT_C180591 hasExactSynonym "Gonadotropin-releasing Hormone Antagonist VERU-100" @default.
- NCIT_C180591 hasExactSynonym "VERU 100" @default.
- NCIT_C180591 hasExactSynonym "VERU-100" @default.
- NCIT_C180591 hasExactSynonym "VERU100" @default.
- NCIT_C180591 inSubset NCIT_C128784 @default.
- NCIT_C180591 inSubset NCIT_C157711 @default.
- NCIT_C180591 inSubset NCIT_C157712 @default.
- NCIT_C180591 inSubset NCIT_C176424 @default.
- NCIT_C180591 type Class @default.
- NCIT_C180591 isDefinedBy ncit.owl @default.
- NCIT_C180591 label "GnRH Antagonist VERU-100" @default.
- NCIT_C180591 subClassOf NCIT_C147908 @default.
- NCIT_C180591 subClassOf NCIT_C180591 @default.
- NCIT_C180591 subClassOf NCIT_C1908 @default.
- NCIT_C180591 subClassOf NCIT_C1909 @default.
- NCIT_C180591 subClassOf NCIT_C2092 @default.
- NCIT_C180591 subClassOf NCIT_C547 @default.