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- NCIT_C180592 IAO_0000115 "A trispecific T-cell enabler targeting the human tumor-associated antigen (TAA) prostate-specific membrane antigen (PSMA; FOLH1), the co-stimulatory receptor 4-1BB (CD137; tumor necrosis factor receptor superfamily member 9; TNFRSF9) and human serum albumin (HSA), with potential immunostimulating and antineoplastic activities. Upon administration, CD137/PSMA/HSA trispecific-targeting agent CB307 simultaneously targets and binds to 4-1BB, which is expressed on a variety of leukocyte subsets including activated T-lymphocytes, and PSMA expressed on tumor cells. The simultaneous binding to PSMA enables clustering of 4-1BB and thereby allows for conditional stimulation of 4-1BB signaling within the tumor microenvironment (TME) only upon binding to PSMA on tumor cells. 4-1BB activation results in T-cell stimulation and enhances T-lymphocyte-mediated anti-tumor immune response against the PSMA-expressing tumor cells. PSMA is overexpressed on the surface of metastatic and hormone-refractory prostate tumor cells. 4-1BB, a surface glycoprotein of the tumor necrosis factor receptor superfamily, is an inducible costimulatory receptor that plays a key role in T-cell proliferation, survival and cytolytic activity. The albumin-binding domain targets and binds to HSA thereby extending the serum half-life of CB307. The conditional activation of 4-1BB signaling prevents systemic T-cell activation and lowers systemic toxicity." @default.
- NCIT_C180592 NCIT_A7 NCIT_C105113 @default.
- NCIT_C180592 NCIT_A7 NCIT_C17796 @default.
- NCIT_C180592 NCIT_NHC0 "C180592" @default.
- NCIT_C180592 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C180592 NCIT_P107 "CD137/PSMA/HSA Trispecific-targeting Agent CB 307" @default.
- NCIT_C180592 NCIT_P108 "CD137/PSMA/HSA Trispecific-targeting Agent CB 307" @default.
- NCIT_C180592 NCIT_P208 "CL1662929" @default.
- NCIT_C180592 NCIT_P322 "CTRP" @default.
- NCIT_C180592 NCIT_P322 "GDC" @default.
- NCIT_C180592 NCIT_P399 "805503" @default.
- NCIT_C180592 normalizedInformationContent "100" @default.
- NCIT_C180592 referenceCount "1" @default.
- NCIT_C180592 hasExactSynonym "CB 307" @default.
- NCIT_C180592 hasExactSynonym "CB-307" @default.
- NCIT_C180592 hasExactSynonym "CB307" @default.
- NCIT_C180592 hasExactSynonym "CD137 x PSMA Humabody CB307" @default.
- NCIT_C180592 hasExactSynonym "CD137/PSMA/HSA Trispecific-targeting Agent CB 307" @default.
- NCIT_C180592 hasExactSynonym "Tri-specific Humabody CB307" @default.
- NCIT_C180592 hasExactSynonym "Trispecific Humabody T-cell Enhancer CB307" @default.
- NCIT_C180592 inSubset NCIT_C116977 @default.
- NCIT_C180592 inSubset NCIT_C116978 @default.
- NCIT_C180592 inSubset NCIT_C128784 @default.
- NCIT_C180592 inSubset NCIT_C157711 @default.
- NCIT_C180592 inSubset NCIT_C157712 @default.
- NCIT_C180592 inSubset NCIT_C176424 @default.
- NCIT_C180592 type Class @default.
- NCIT_C180592 isDefinedBy ncit.owl @default.
- NCIT_C180592 label "CD137/PSMA/HSA Trispecific-targeting Agent CB 307" @default.
- NCIT_C180592 subClassOf NCIT_C129820 @default.
- NCIT_C180592 subClassOf NCIT_C163758 @default.
- NCIT_C180592 subClassOf NCIT_C176017 @default.
- NCIT_C180592 subClassOf NCIT_C180592 @default.
- NCIT_C180592 subClassOf NCIT_C1908 @default.
- NCIT_C180592 subClassOf NCIT_C1909 @default.
- NCIT_C180592 subClassOf NCIT_C192997 @default.
- NCIT_C180592 subClassOf NCIT_C274 @default.
- NCIT_C180592 subClassOf NCIT_C308 @default.