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- NCIT_C180595 IAO_0000115 "A T-cell engaging bispecific antibody and Conditional Bispecific Redirected Activation (COBRA) protein targeting both the tumor-associated antigen (TAA) epidermal growth factor receptor (EGFR; HER1; ErbB1) and the T-cell surface antigen CD3, and containing a protease cleavable linker and a human serum albumin (HSA) binding part, with potential immunostimulating and antineoplastic activities. Upon administration, EGFR/CD3-targeting T-cell engaging moleculeTAK-186 is cleaved by proteases in the tumor microenvironment (TME). Upon cleavage, TAK-186 dimerizes to form the active molecule and binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and EGFR on EGFR-expressing tumor cells. This activates and redirects CTLs to EGFR-expressing tumor cells, leading to CTL-mediated killing of EGFR-expressing tumor cells. EGFR, upregulated and/or mutated in a variety of tumor cell types, plays a key role in tumor cell proliferation. The albumin-binding domain targets and binds to serum albumin, thereby extending the serum half-life of the inactivated TAK-186. Upon cleavage of the HSA-binding component, the activated TAK-186 dimer will be eliminated after cancer cell killing; this improves the safety profile of this agent by reducing its ability to cause damage to healthy cells." @default.
- NCIT_C180595 NCIT_NHC0 "C180595" @default.
- NCIT_C180595 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C180595 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C180595 NCIT_P107 "EGFR/CD3-targeting T-cell Engaging Molecule TAK-186" @default.
- NCIT_C180595 NCIT_P108 "EGFR/CD3-targeting T-cell Engaging Molecule TAK-186" @default.
- NCIT_C180595 NCIT_P208 "CL1662926" @default.
- NCIT_C180595 NCIT_P322 "CTRP" @default.
- NCIT_C180595 NCIT_P322 "GDC" @default.
- NCIT_C180595 NCIT_P399 "805508" @default.
- NCIT_C180595 NCIT_R124 NCIT_C17710 @default.
- NCIT_C180595 NCIT_R124 NCIT_C17828 @default.
- NCIT_C180595 NCIT_R124 NCIT_C18219 @default.
- NCIT_C180595 NCIT_R124 NCIT_C19986 @default.
- NCIT_C180595 NCIT_R124 NCIT_C40474 @default.
- NCIT_C180595 normalizedInformationContent "100" @default.
- NCIT_C180595 referenceCount "1" @default.
- NCIT_C180595 hasExactSynonym "COBRA Protein MVC-101" @default.
- NCIT_C180595 hasExactSynonym "Conditionally Active T- cell Engager MVC-101" @default.
- NCIT_C180595 hasExactSynonym "EGFR x CD3 Conditional Bispecific Redirected Activation Protein MVC-101" @default.
- NCIT_C180595 hasExactSynonym "EGFR/CD3-engaging Conditionally Active Bispecific Antibody MVC-101" @default.
- NCIT_C180595 hasExactSynonym "EGFR/CD3-targeting T-cell Engaging Molecule TAK-186" @default.
- NCIT_C180595 hasExactSynonym "MVC 101" @default.
- NCIT_C180595 hasExactSynonym "MVC-101" @default.
- NCIT_C180595 hasExactSynonym "MVC101" @default.
- NCIT_C180595 hasExactSynonym "TAK 186" @default.
- NCIT_C180595 hasExactSynonym "TAK-186" @default.
- NCIT_C180595 hasExactSynonym "TAK186" @default.
- NCIT_C180595 inSubset NCIT_C116977 @default.
- NCIT_C180595 inSubset NCIT_C116978 @default.
- NCIT_C180595 inSubset NCIT_C128784 @default.
- NCIT_C180595 inSubset NCIT_C157711 @default.
- NCIT_C180595 inSubset NCIT_C157712 @default.
- NCIT_C180595 inSubset NCIT_C176424 @default.
- NCIT_C180595 type Class @default.
- NCIT_C180595 isDefinedBy ncit.owl @default.
- NCIT_C180595 label "EGFR/CD3-targeting T-cell Engaging Molecule TAK-186" @default.
- NCIT_C180595 subClassOf NCIT_C112883 @default.
- NCIT_C180595 subClassOf NCIT_C129821 @default.
- NCIT_C180595 subClassOf NCIT_C129822 @default.
- NCIT_C180595 subClassOf NCIT_C1454 @default.
- NCIT_C180595 subClassOf NCIT_C180595 @default.
- NCIT_C180595 subClassOf NCIT_C1908 @default.
- NCIT_C180595 subClassOf NCIT_C1909 @default.
- NCIT_C180595 subClassOf NCIT_C201282 @default.
- NCIT_C180595 subClassOf NCIT_C20401 @default.
- NCIT_C180595 subClassOf NCIT_C274 @default.
- NCIT_C180595 subClassOf NCIT_C28227 @default.
- NCIT_C180595 subClassOf NCIT_C307 @default.
- NCIT_C180595 subClassOf NCIT_C308 @default.