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- NCIT_C180596 IAO_0000115 "A preparation of autologous CD4/CD8 enriched T-lymphocytes engineered to express pLTG1497, a tandem chimeric antigen receptor (CAR) specific for the two tumor-associated antigens (TAAs) cluster of differentiation 19 (CD19) and CD20, with potential immunostimulating and antineoplastic activities. Upon administration, zamtocabtagene autoleucel target and bind to CD19- and CD20-expressing tumor B-cells. This induces selective toxicity in tumor B-cells expressing these TAAs. Both CD19 and CD20 are B-cell-specific cell surface antigens overexpressed in B-cell lineage malignancies. Targeting both CD19 and CD20 may prevent tumor cell antigen escape and relapse." @default.
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- NCIT_C180596 hasExactSynonym "Autologous Anti-CD20/CD19-targeting Tandem CAR T Cells MB-CART2019.1" @default.
- NCIT_C180596 hasExactSynonym "Autologous pLTG1497-transduced CAR T-cells MB-CART2019.1" @default.
- NCIT_C180596 hasExactSynonym "MB CART2019.1" @default.
- NCIT_C180596 hasExactSynonym "MB-CART2019.1" @default.
- NCIT_C180596 hasExactSynonym "MBCART2019.1" @default.
- NCIT_C180596 hasExactSynonym "ZAMTOCABTAGENE AUTOLEUCEL" @default.
- NCIT_C180596 hasExactSynonym "Zamtocabtagene Autoleucel" @default.
- NCIT_C180596 inSubset NCIT_C116977 @default.
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- NCIT_C180596 type Class @default.
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- NCIT_C180596 label "Zamtocabtagene Autoleucel" @default.
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