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- NCIT_C1806 IAO_0000115 "A recombinant, humanized anti-CD33 monoclonal antibody attached to the cytotoxic antitumor antibiotic calicheamicin. In this conjugate, the antibody binds to and is internalized by tumor cells expressing CD33 antigen (a sialic acid-dependent glycoprotein commonly found on the surface of leukemic blasts), thereby delivering the attached calicheamicin to CD33-expressing tumor cells. Calicheamicin binds to the minor groove of DNA, causing double strand DNA breaks and resulting in inhibition of DNA synthesis. (NCI04)" @default.
- NCIT_C1806 NCIT_A24 NCIT_C274 @default.
- NCIT_C1806 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1806 NCIT_A7 NCIT_C97246 @default.
- NCIT_C1806 NCIT_NHC0 "C1806" @default.
- NCIT_C1806 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C1806 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1806 NCIT_P107 "Gemtuzumab Ozogamicin" @default.
- NCIT_C1806 NCIT_P108 "Gemtuzumab Ozogamicin" @default.
- NCIT_C1806 NCIT_P175 "720568" @default.
- NCIT_C1806 NCIT_P207 "C1533699" @default.
- NCIT_C1806 NCIT_P210 "220578-59-6" @default.
- NCIT_C1806 NCIT_P302 "Acute Myeloid Leukemia." @default.
- NCIT_C1806 NCIT_P319 "8GZG754X6M" @default.
- NCIT_C1806 NCIT_P322 "CTRP" @default.
- NCIT_C1806 NCIT_P322 "FDA" @default.
- NCIT_C1806 NCIT_P322 "GDC" @default.
- NCIT_C1806 NCIT_P322 "PCDC" @default.
- NCIT_C1806 NCIT_P325 "A monoclonal antibody combined with a toxic substance that is used to treat certain types of acute myeloid leukemia in older patients and is being studied in the treatment of other types of cancer. Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells. Mylotarg is a type of antibody-drug conjugate." @default.
- NCIT_C1806 NCIT_P329 "42868" @default.
- NCIT_C1806 NCIT_P330 "42868" @default.
- NCIT_C1806 NCIT_P350 "C73H96IN6O25S3" @default.
- NCIT_C1806 NCIT_P366 "Gemtuzumab_Ozogamicin" @default.
- NCIT_C1806 NCIT_P375 "Gemtuzumab Ozogamicin" @default.
- NCIT_C1806 NCIT_P399 "42868" @default.
- NCIT_C1806 normalizedInformationContent "81.653330900245635" @default.
- NCIT_C1806 referenceCount "16" @default.
- NCIT_C1806 hasExactSynonym "CDP-771" @default.
- NCIT_C1806 hasExactSynonym "CMA-676" @default.
- NCIT_C1806 hasExactSynonym "Calicheamicin-Conjugated Humanized Anti-CD33 Monoclonal Antibody" @default.
- NCIT_C1806 hasExactSynonym "GEMTUZUMAB OZOGAMICIN" @default.
- NCIT_C1806 hasExactSynonym "Gemtuzumab Ozogamicin" @default.
- NCIT_C1806 hasExactSynonym "Mylotarg" @default.
- NCIT_C1806 hasExactSynonym "WAY-CMA-676" @default.
- NCIT_C1806 hasExactSynonym "gemtuzumab ozogamicin" @default.
- NCIT_C1806 hasExactSynonym "gemtuzumab" @default.
- NCIT_C1806 hasExactSynonym "hP67.6-Calicheamicin" @default.
- NCIT_C1806 inSubset NCIT_C116977 @default.
- NCIT_C1806 inSubset NCIT_C116978 @default.
- NCIT_C1806 inSubset NCIT_C128784 @default.
- NCIT_C1806 inSubset NCIT_C157711 @default.
- NCIT_C1806 inSubset NCIT_C157712 @default.
- NCIT_C1806 inSubset NCIT_C173234 @default.
- NCIT_C1806 inSubset NCIT_C174019 @default.
- NCIT_C1806 inSubset NCIT_C176424 @default.
- NCIT_C1806 inSubset NCIT_C177537 @default.
- NCIT_C1806 inSubset NCIT_C63923 @default.
- NCIT_C1806 type Class @default.
- NCIT_C1806 isDefinedBy ncit.owl @default.
- NCIT_C1806 label "Gemtuzumab Ozogamicin" @default.
- NCIT_C1806 subClassOf NCIT_C129821 @default.
- NCIT_C1806 subClassOf NCIT_C129823 @default.
- NCIT_C1806 subClassOf NCIT_C1512 @default.
- NCIT_C1806 subClassOf NCIT_C1806 @default.
- NCIT_C1806 subClassOf NCIT_C1908 @default.
- NCIT_C1806 subClassOf NCIT_C1909 @default.
- NCIT_C1806 subClassOf NCIT_C2333 @default.
- NCIT_C1806 subClassOf NCIT_C274 @default.
- NCIT_C1806 subClassOf NCIT_C307 @default.
- NCIT_C1806 subClassOf NCIT_C308 @default.