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- NCIT_C180622 IAO_0000115 "The mesylate salt form of temuterkib, an orally available inhibitor of extracellular signal-regulated kinase (ERK) 1 and 2, with potential antineoplastic activity. Upon oral administration, temuterkib inhibits both ERK 1 and 2, thereby preventing the activation of mitogen-activated protein kinase (MAPK)/ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. The MAPK/ERK pathway is often upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival." @default.
- NCIT_C180622 NCIT_A7 NCIT_C17589 @default.
- NCIT_C180622 NCIT_NHC0 "C180622" @default.
- NCIT_C180622 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C180622 NCIT_P108 "Temuterkib Mesylate" @default.
- NCIT_C180622 NCIT_P208 "CL1663436" @default.
- NCIT_C180622 NCIT_P210 "2365171-00-0" @default.
- NCIT_C180622 NCIT_P319 "34M62WSA87" @default.
- NCIT_C180622 NCIT_P322 "FDA" @default.
- NCIT_C180622 NCIT_P322 "GDC" @default.
- NCIT_C180622 normalizedInformationContent "100" @default.
- NCIT_C180622 referenceCount "1" @default.
- NCIT_C180622 hasExactSynonym "ERK1/2 Inhibitor LY3214996 Mesylate" @default.
- NCIT_C180622 hasExactSynonym "LY 3214996 Mesylate" @default.
- NCIT_C180622 hasExactSynonym "LY-3214996 Mesylate" @default.
- NCIT_C180622 hasExactSynonym "LY3214996 Mesylate" @default.
- NCIT_C180622 hasExactSynonym "TEMUTERKIB MESYLATE" @default.
- NCIT_C180622 hasExactSynonym "Temuterkib Mesylate" @default.
- NCIT_C180622 inSubset NCIT_C128784 @default.
- NCIT_C180622 inSubset NCIT_C157711 @default.
- NCIT_C180622 inSubset NCIT_C157712 @default.
- NCIT_C180622 inSubset NCIT_C176424 @default.
- NCIT_C180622 inSubset NCIT_C63923 @default.
- NCIT_C180622 type Class @default.
- NCIT_C180622 isDefinedBy ncit.owl @default.
- NCIT_C180622 label "Temuterkib Mesylate" @default.
- NCIT_C180622 subClassOf NCIT_C129824 @default.
- NCIT_C180622 subClassOf NCIT_C129825 @default.
- NCIT_C180622 subClassOf NCIT_C1404 @default.
- NCIT_C180622 subClassOf NCIT_C174048 @default.
- NCIT_C180622 subClassOf NCIT_C180622 @default.
- NCIT_C180622 subClassOf NCIT_C1908 @default.
- NCIT_C180622 subClassOf NCIT_C1909 @default.
- NCIT_C180622 subClassOf NCIT_C2189 @default.
- NCIT_C180622 subClassOf NCIT_C274 @default.
- NCIT_C180622 subClassOf NCIT_C471 @default.
- NCIT_C180622 subClassOf NCIT_C61074 @default.