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- NCIT_C180668 IAO_0000115 "A fourth-generation, orally bioavailable, mutant-selective, epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity. Upon oral administration, EGFR mutant-selective inhibitor BLU-945 targets, binds to and inhibits the activity of EGFR with C797S triple mutations including ex19del/T790M/C797S and L858R/T790M/C797S, thereby preventing EGFR-mediated signaling. This may both induce cell death and inhibit tumor growth in EGFR-overexpressing tumor cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization. BLU-945 inhibits mutated forms of EGFR with C797S mutation, which prevents covalent bond formation with third-generation EGFR inhibitors leading to drug resistance. BLU-945 may have enhanced anti-tumor effects in tumors with C797S-mediated resistance when compared to other EGFR tyrosine kinase inhibitors." @default.
- NCIT_C180668 NCIT_A7 NCIT_C126892 @default.
- NCIT_C180668 NCIT_A7 NCIT_C147011 @default.
- NCIT_C180668 NCIT_A7 NCIT_C98503 @default.
- NCIT_C180668 NCIT_A7 NCIT_C98515 @default.
- NCIT_C180668 NCIT_NHC0 "C180668" @default.
- NCIT_C180668 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C180668 NCIT_P107 "EGFR Mutant-selective Inhibitor BLU-945" @default.
- NCIT_C180668 NCIT_P108 "EGFR Mutant-selective Inhibitor BLU-945" @default.
- NCIT_C180668 NCIT_P208 "CL1663390" @default.
- NCIT_C180668 NCIT_P210 "2660250-10-0" @default.
- NCIT_C180668 NCIT_P319 "PA4PTH5HL9" @default.
- NCIT_C180668 NCIT_P322 "CTRP" @default.
- NCIT_C180668 NCIT_P322 "FDA" @default.
- NCIT_C180668 NCIT_P322 "GDC" @default.
- NCIT_C180668 NCIT_P399 "805549" @default.
- NCIT_C180668 normalizedInformationContent "100" @default.
- NCIT_C180668 referenceCount "1" @default.
- NCIT_C180668 hasExactSynonym "BLU 945" @default.
- NCIT_C180668 hasExactSynonym "BLU-945" @default.
- NCIT_C180668 hasExactSynonym "BLU945" @default.
- NCIT_C180668 hasExactSynonym "EGFR Inhibitor BLU-945" @default.
- NCIT_C180668 hasExactSynonym "EGFR Mutant-selective Inhibitor BLU-945" @default.
- NCIT_C180668 inSubset NCIT_C116977 @default.
- NCIT_C180668 inSubset NCIT_C116978 @default.
- NCIT_C180668 inSubset NCIT_C128784 @default.
- NCIT_C180668 inSubset NCIT_C157711 @default.
- NCIT_C180668 inSubset NCIT_C157712 @default.
- NCIT_C180668 inSubset NCIT_C176424 @default.
- NCIT_C180668 inSubset NCIT_C63923 @default.
- NCIT_C180668 type Class @default.
- NCIT_C180668 isDefinedBy ncit.owl @default.
- NCIT_C180668 label "EGFR Mutant-selective Inhibitor BLU-945" @default.
- NCIT_C180668 subClassOf NCIT_C129824 @default.
- NCIT_C180668 subClassOf NCIT_C129825 @default.
- NCIT_C180668 subClassOf NCIT_C1404 @default.
- NCIT_C180668 subClassOf NCIT_C163758 @default.
- NCIT_C180668 subClassOf NCIT_C163952 @default.
- NCIT_C180668 subClassOf NCIT_C180668 @default.
- NCIT_C180668 subClassOf NCIT_C1908 @default.
- NCIT_C180668 subClassOf NCIT_C1909 @default.
- NCIT_C180668 subClassOf NCIT_C1967 @default.
- NCIT_C180668 subClassOf NCIT_C2167 @default.
- NCIT_C180668 subClassOf NCIT_C2189 @default.
- NCIT_C180668 subClassOf NCIT_C274 @default.
- NCIT_C180668 subClassOf NCIT_C471 @default.