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- NCIT_C180671 IAO_0000115 "A topical cream formulation containing the proton pump inhibitor (PPI) esomeprazole, with potential antioxidant, anti-inflammatory and antifibrotic activities. Upon topical administration, esomeprazole inhibits the enzyme dimethylarginine dimethylaminohydrolase (DDAH), which increases the levels of the nitric oxide synthase (NOS) inhibitor asymmetric dimethylarginine (ADMA). In addition, esomeprazole increases the expression of the antioxidant enzyme heme oxygenase-1 (HO-1). Together, these actions reduce oxidative stress which may protect cells from reactive oxygen species (ROS), cellular damage, inflammation and fibrosis." @default.
- NCIT_C180671 NCIT_NHC0 "C180671" @default.
- NCIT_C180671 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C180671 NCIT_P108 "Esomeprazole Topical Cream" @default.
- NCIT_C180671 NCIT_P208 "CL1663393" @default.
- NCIT_C180671 NCIT_P399 "805555" @default.
- NCIT_C180671 normalizedInformationContent "100" @default.
- NCIT_C180671 referenceCount "1" @default.
- NCIT_C180671 hasExactSynonym "Dermaprazole" @default.
- NCIT_C180671 hasExactSynonym "Esomeprazole Topical Cream" @default.
- NCIT_C180671 inSubset NCIT_C176424 @default.
- NCIT_C180671 type Class @default.
- NCIT_C180671 isDefinedBy ncit.owl @default.
- NCIT_C180671 label "Esomeprazole Topical Cream" @default.
- NCIT_C180671 subClassOf NCIT_C180671 @default.
- NCIT_C180671 subClassOf NCIT_C1908 @default.
- NCIT_C180671 subClassOf NCIT_C1909 @default.
- NCIT_C180671 subClassOf NCIT_C29629 @default.
- NCIT_C180671 subClassOf NCIT_C29639 @default.