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- NCIT_C180675 IAO_0000115 "A bispecific antibody directed against both the immunosuppressive ligand programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274) and the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18), with potential immune checkpoint inhibitory, immunostimulatory and antineoplastic activities. Upon administration, anti-PD-L1/Claudin18.2 bispecific antibody Q-1802 targets and simultaneously binds to both PD-L1 and CLDN18.2 expressed on certain types of tumor cells. This prevents the binding of PD-L1 to its receptor, programmed cell death protein 1 (PD-1, CD279), inhibits the PD-1-mediated signaling, and inhibits the PD-1-mediated downregulation of T-cell activation and proliferation. This restores and enhances a cytotoxic T-lymphocyte (CTL)-mediated immune response against CLDN18.2-expressing tumor cells. PD-L1, which is overexpressed in many human cancer cell types, plays an important role in the downregulation of the immune system and tumor evasion from host immunity. CLDN18.2, a tight junction protein and stomach-specific isoform of claudin-18, is expressed on a variety of tumor cells, but its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa." @default.
- NCIT_C180675 NCIT_A7 NCIT_C150412 @default.
- NCIT_C180675 NCIT_A7 NCIT_C96024 @default.
- NCIT_C180675 NCIT_NHC0 "C180675" @default.
- NCIT_C180675 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C180675 NCIT_P108 "Anti-PD-L1/Claudin18.2 Bispecific Antibody Q-1802" @default.
- NCIT_C180675 NCIT_P208 "CL1663334" @default.
- NCIT_C180675 NCIT_P322 "GDC" @default.
- NCIT_C180675 NCIT_P399 "805543" @default.
- NCIT_C180675 NCIT_R124 NCIT_C17710 @default.
- NCIT_C180675 NCIT_R124 NCIT_C17828 @default.
- NCIT_C180675 NCIT_R124 NCIT_C18219 @default.
- NCIT_C180675 NCIT_R124 NCIT_C19986 @default.
- NCIT_C180675 NCIT_R124 NCIT_C40474 @default.
- NCIT_C180675 normalizedInformationContent "100" @default.
- NCIT_C180675 referenceCount "1" @default.
- NCIT_C180675 hasExactSynonym "Anti-PD-L1/Claudin18.2 Bispecific Antibody Q-1802" @default.
- NCIT_C180675 hasExactSynonym "Q 1802" @default.
- NCIT_C180675 hasExactSynonym "Q-1802" @default.
- NCIT_C180675 hasExactSynonym "Q1802" @default.
- NCIT_C180675 inSubset NCIT_C128784 @default.
- NCIT_C180675 inSubset NCIT_C157711 @default.
- NCIT_C180675 inSubset NCIT_C157712 @default.
- NCIT_C180675 inSubset NCIT_C176424 @default.
- NCIT_C180675 type Class @default.
- NCIT_C180675 isDefinedBy ncit.owl @default.
- NCIT_C180675 label "Anti-PD-L1/Claudin18.2 Bispecific Antibody Q-1802" @default.
- NCIT_C180675 subClassOf NCIT_C128057 @default.
- NCIT_C180675 subClassOf NCIT_C129821 @default.
- NCIT_C180675 subClassOf NCIT_C129822 @default.
- NCIT_C180675 subClassOf NCIT_C141144 @default.
- NCIT_C180675 subClassOf NCIT_C143250 @default.
- NCIT_C180675 subClassOf NCIT_C1454 @default.
- NCIT_C180675 subClassOf NCIT_C156893 @default.
- NCIT_C180675 subClassOf NCIT_C163758 @default.
- NCIT_C180675 subClassOf NCIT_C179676 @default.
- NCIT_C180675 subClassOf NCIT_C180675 @default.
- NCIT_C180675 subClassOf NCIT_C1908 @default.
- NCIT_C180675 subClassOf NCIT_C1909 @default.
- NCIT_C180675 subClassOf NCIT_C191689 @default.
- NCIT_C180675 subClassOf NCIT_C200250 @default.
- NCIT_C180675 subClassOf NCIT_C20401 @default.
- NCIT_C180675 subClassOf NCIT_C274 @default.
- NCIT_C180675 subClassOf NCIT_C307 @default.
- NCIT_C180675 subClassOf NCIT_C308 @default.