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- NCIT_C180687 IAO_0000115 "A fully humanized, Fc-engineered monoclonal antibody with masked antigen-binding regions directed against the human T-cell-expressed receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA4; CTLA-4), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration and the activation of the antigen-binding regions via cleavage by proteases that are upregulated in the tumor microenvironment (TME), anti-CTLA-4 monoclonal antibody XTX101 targets and binds to CTLA-4 expressed on T-cells and inhibits the CTLA-4-mediated downregulation of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells, thereby killing cancer cells. CTLA-4, an inhibitory receptor and member of the immunoglobulin superfamily (IgSF), plays a key role in the downregulation of the immune system." @default.
- NCIT_C180687 NCIT_A7 NCIT_C17489 @default.
- NCIT_C180687 NCIT_NHC0 "C180687" @default.
- NCIT_C180687 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C180687 NCIT_P107 "Anti-CTLA-4 Monoclonal Antibody XTX101" @default.
- NCIT_C180687 NCIT_P108 "Anti-CTLA-4 Monoclonal Antibody XTX101" @default.
- NCIT_C180687 NCIT_P208 "CL1663330" @default.
- NCIT_C180687 NCIT_P322 "CTRP" @default.
- NCIT_C180687 NCIT_P322 "GDC" @default.
- NCIT_C180687 NCIT_P399 "805575" @default.
- NCIT_C180687 NCIT_R124 NCIT_C17710 @default.
- NCIT_C180687 NCIT_R124 NCIT_C17828 @default.
- NCIT_C180687 NCIT_R124 NCIT_C18219 @default.
- NCIT_C180687 NCIT_R124 NCIT_C19986 @default.
- NCIT_C180687 NCIT_R124 NCIT_C40474 @default.
- NCIT_C180687 normalizedInformationContent "100" @default.
- NCIT_C180687 referenceCount "1" @default.
- NCIT_C180687 hasExactSynonym "Anti-CTLA-4 Monoclonal Antibody XTX101" @default.
- NCIT_C180687 hasExactSynonym "XTX 101" @default.
- NCIT_C180687 hasExactSynonym "XTX-101" @default.
- NCIT_C180687 hasExactSynonym "XTX101" @default.
- NCIT_C180687 inSubset NCIT_C116977 @default.
- NCIT_C180687 inSubset NCIT_C116978 @default.
- NCIT_C180687 inSubset NCIT_C128784 @default.
- NCIT_C180687 inSubset NCIT_C157711 @default.
- NCIT_C180687 inSubset NCIT_C157712 @default.
- NCIT_C180687 inSubset NCIT_C176424 @default.
- NCIT_C180687 type Class @default.
- NCIT_C180687 isDefinedBy ncit.owl @default.
- NCIT_C180687 label "Anti-CTLA-4 Monoclonal Antibody XTX101" @default.
- NCIT_C180687 subClassOf NCIT_C128036 @default.
- NCIT_C180687 subClassOf NCIT_C129821 @default.
- NCIT_C180687 subClassOf NCIT_C129822 @default.
- NCIT_C180687 subClassOf NCIT_C141144 @default.
- NCIT_C180687 subClassOf NCIT_C143250 @default.
- NCIT_C180687 subClassOf NCIT_C163758 @default.
- NCIT_C180687 subClassOf NCIT_C180687 @default.
- NCIT_C180687 subClassOf NCIT_C1908 @default.
- NCIT_C180687 subClassOf NCIT_C1909 @default.
- NCIT_C180687 subClassOf NCIT_C191738 @default.
- NCIT_C180687 subClassOf NCIT_C20401 @default.
- NCIT_C180687 subClassOf NCIT_C274 @default.
- NCIT_C180687 subClassOf NCIT_C307 @default.
- NCIT_C180687 subClassOf NCIT_C308 @default.