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- NCIT_C180692 IAO_0000115 "A micelle nanoparticle formulation composed of the Toll-Like receptor 7 (TLR7) agonist phospholipid conjugate 1v270 encapsulated within 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE)-polyethylene glycol (PEG)-2000, with potential immunostimulating activity. Upon intravenous administration of the nanoparticles encapsulating TLR7 agonist 1v270 MBS8, the TLR7 agonist targets, binds to and activates TLR7, thereby stimulating dendritic cells (DCs) and neutrophils, and enhancing natural killer cell (NK) cytotoxicity. This activation results in the production of pro-inflammatory cytokines, including interferon alpha. MBS8 may activate cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune responses leading to tumor cell lysis. In addition, MBS8 is able to stimulate immune memory T-cells to further recognize and eliminate cancer cells. TLR7 is a member of the TLR family, which plays a fundamental role in pathogen recognition and the activation of innate immunity. The micelle formulation was engineered to reduce systemic cytokine production which may lower systemic toxicity. production which may lower systemic toxicity." @default.
- NCIT_C180692 NCIT_A7 NCIT_C30108 @default.
- NCIT_C180692 NCIT_NHC0 "C180692" @default.
- NCIT_C180692 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C180692 NCIT_P108 "Nanoparticles Encapsulating TLR7 Agonist 1v270 MBS8" @default.
- NCIT_C180692 NCIT_P208 "CL1663323" @default.
- NCIT_C180692 NCIT_P322 "GDC" @default.
- NCIT_C180692 NCIT_P399 "805536" @default.
- NCIT_C180692 normalizedInformationContent "100" @default.
- NCIT_C180692 referenceCount "1" @default.
- NCIT_C180692 hasExactSynonym "DOPE-PEG2000/1v270 Micelles MBS8" @default.
- NCIT_C180692 hasExactSynonym "MBS 8" @default.
- NCIT_C180692 hasExactSynonym "MBS-8" @default.
- NCIT_C180692 hasExactSynonym "MBS8" @default.
- NCIT_C180692 hasExactSynonym "MBS8(1V270)" @default.
- NCIT_C180692 hasExactSynonym "Nanoparticles Encapsulating TLR7 Agonist 1v270 MBS8" @default.
- NCIT_C180692 hasExactSynonym "TLR7 Agonist 1v270-containing Micelles MBS8" @default.
- NCIT_C180692 inSubset NCIT_C128784 @default.
- NCIT_C180692 inSubset NCIT_C157711 @default.
- NCIT_C180692 inSubset NCIT_C157712 @default.
- NCIT_C180692 inSubset NCIT_C176424 @default.
- NCIT_C180692 type Class @default.
- NCIT_C180692 isDefinedBy ncit.owl @default.
- NCIT_C180692 label "Nanoparticles Encapsulating TLR7 Agonist 1v270 MBS8" @default.
- NCIT_C180692 subClassOf NCIT_C177174 @default.
- NCIT_C180692 subClassOf NCIT_C177176 @default.
- NCIT_C180692 subClassOf NCIT_C180692 @default.
- NCIT_C180692 subClassOf NCIT_C1908 @default.
- NCIT_C180692 subClassOf NCIT_C1909 @default.
- NCIT_C180692 subClassOf NCIT_C2139 @default.
- NCIT_C180692 subClassOf NCIT_C308 @default.