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- NCIT_C180699 IAO_0000115 "A Toll-like receptor 9 (TLR9) agonist/STAT3 siRNA conjugate composed of a CpG oligodeoxynucleotide (ODN) and a short interfering RNA (siRNAs) directed against signal transducer and activator of transcription 3 (STAT3), with potential immunostimulating and antineoplastic activities. Upon administration of CpG-STAT3 siRNA CAS3/SS3, the CpG ODN moiety binds to and activates TLR9, and the conjugate is internalized by various antigen-presenting cells (APCs), including dendritic cells (DCs), macrophages and B-cells. This activates numerous signaling transduction pathways which results in the release of multiple cytokines, such as immunoglobulins (Igs), interferons (IFNs), interleukins (ILs) and tumor necrosis factor (TNF) and induces innate and adaptive immune responses. In addition, the internalization results in the delivery of anti-STAT siRNA moiety into myeloid and B-cells. The siRNA binds to STAT mRNA and inhibits both the translation and expression of the STAT protein. This prevents STAT3 binding to responsive gene promoters and blocks STAT3-mediated regulation of gene expression. STAT3 regulates the transcription of genes involved in several cellular functions. It is constitutively activated in a variety of human cancers and plays a key role in neoplastic transformation, uncontrolled tumor cell proliferation, resistance to apoptosis, metastasis, immune evasion, tumor angiogenesis, epithelial-mesenchymal transition (EMT) and the Warburg effect. Altogether, this may result in tumor cell death and inhibit tumor cell proliferation, angiogenesis and metastasis." @default.
- NCIT_C180699 NCIT_A7 NCIT_C28664 @default.
- NCIT_C180699 NCIT_A7 NCIT_C96048 @default.
- NCIT_C180699 NCIT_NHC0 "C180699" @default.
- NCIT_C180699 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C180699 NCIT_P107 "CpG-STAT3 siRNA CAS3/SS3" @default.
- NCIT_C180699 NCIT_P108 "CpG-STAT3 siRNA CAS3/SS3" @default.
- NCIT_C180699 NCIT_P208 "CL1663315" @default.
- NCIT_C180699 NCIT_P322 "CTRP" @default.
- NCIT_C180699 NCIT_P322 "GDC" @default.
- NCIT_C180699 NCIT_P399 "813349" @default.
- NCIT_C180699 normalizedInformationContent "100" @default.
- NCIT_C180699 referenceCount "1" @default.
- NCIT_C180699 hasExactSynonym "CAS3/SS3" @default.
- NCIT_C180699 hasExactSynonym "CpG ODN/STAT3 siRNA CAS3/SS3" @default.
- NCIT_C180699 hasExactSynonym "CpG Oligodeoxynucleotide/STAT3 siRNA CAS3/SS3" @default.
- NCIT_C180699 hasExactSynonym "CpG-STAT3 siRNA CAS3/SS3" @default.
- NCIT_C180699 hasExactSynonym "CpG/Anti-STAT3 siRNA CAS3/SS3" @default.
- NCIT_C180699 hasExactSynonym "CpG/STAT3 siRNA CAS3/SS3" @default.
- NCIT_C180699 hasExactSynonym "TLR9 Agonist/STAT3 siRNA Conjugate CAS3/SS3" @default.
- NCIT_C180699 inSubset NCIT_C116977 @default.
- NCIT_C180699 inSubset NCIT_C116978 @default.
- NCIT_C180699 inSubset NCIT_C128784 @default.
- NCIT_C180699 inSubset NCIT_C157711 @default.
- NCIT_C180699 inSubset NCIT_C157712 @default.
- NCIT_C180699 type Class @default.
- NCIT_C180699 isDefinedBy ncit.owl @default.
- NCIT_C180699 label "CpG-STAT3 siRNA CAS3/SS3" @default.
- NCIT_C180699 subClassOf NCIT_C129821 @default.
- NCIT_C180699 subClassOf NCIT_C180699 @default.
- NCIT_C180699 subClassOf NCIT_C1908 @default.
- NCIT_C180699 subClassOf NCIT_C1909 @default.
- NCIT_C180699 subClassOf NCIT_C274 @default.
- NCIT_C180699 subClassOf NCIT_C307 @default.