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- NCIT_C1808 IAO_0000115 "A radioconjugate of biotin and yttrium Y 90 (Y-90) linked through the bifunctional macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA) with radioimmunotherapy property. Biotin is a water-soluble B-complex vitamin, present in minute amounts in every living cell, while its level in cancerous tissue is higher than that of normal tissue. Y 90-DOTA-Biotin could be used in 3-step pre-targeting radioimmunotherapy that employs a tumor targeting antibody conjugated with streptavidin, the natural ligand of biotin." @default.
- NCIT_C1808 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1808 NCIT_NHC0 "C1808" @default.
- NCIT_C1808 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1808 NCIT_P108 "Yttrium Y 90-DOTA-Biotin" @default.
- NCIT_C1808 NCIT_P207 "C0677849" @default.
- NCIT_C1808 NCIT_P322 "GDC" @default.
- NCIT_C1808 NCIT_P325 "A compound that contains the radioisotope yttrium Y 90 linked to the chemical biotin. Biotin is a molecule that binds strongly to the chemical streptavidin. Yttrium Y 90 DOTA-biotin will find tumor cells in the body that have been targeted by an antibody linked to streptavidin and kill them. It is being studied together with CC49-streptavidin in the treatment of cancer." @default.
- NCIT_C1808 NCIT_P329 "365680" @default.
- NCIT_C1808 NCIT_P330 "365680" @default.
- NCIT_C1808 NCIT_P366 "_90Y-DOTA-Biotin" @default.
- NCIT_C1808 NCIT_P375 "Yttrium Y 90-DOTA-Biotin" @default.
- NCIT_C1808 NCIT_P399 "365680" @default.
- NCIT_C1808 normalizedInformationContent "100" @default.
- NCIT_C1808 referenceCount "1" @default.
- NCIT_C1808 hasExactSynonym "90Y-DOTA-Biotin" @default.
- NCIT_C1808 hasExactSynonym "90Y-DOTA-biotin" @default.
- NCIT_C1808 hasExactSynonym "Yttrium Y 90-DOTA-Biotin" @default.
- NCIT_C1808 hasExactSynonym "yttrium Y 90 DOTA-biotin" @default.
- NCIT_C1808 inSubset NCIT_C128784 @default.
- NCIT_C1808 inSubset NCIT_C157711 @default.
- NCIT_C1808 inSubset NCIT_C157712 @default.
- NCIT_C1808 inSubset NCIT_C176424 @default.
- NCIT_C1808 inSubset NCIT_C177537 @default.
- NCIT_C1808 type Class @default.
- NCIT_C1808 isDefinedBy ncit.owl @default.
- NCIT_C1808 label "Yttrium Y 90-DOTA-Biotin" @default.
- NCIT_C1808 subClassOf NCIT_C129819 @default.
- NCIT_C1808 subClassOf NCIT_C1446 @default.
- NCIT_C1808 subClassOf NCIT_C1808 @default.
- NCIT_C1808 subClassOf NCIT_C1908 @default.
- NCIT_C1808 subClassOf NCIT_C1909 @default.
- NCIT_C1808 subClassOf NCIT_C2124 @default.
- NCIT_C1808 subClassOf NCIT_C274 @default.