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- NCIT_C180806 IAO_0000115 "A radioconjugate composed of FAP-2286, a fibroblast activation protein (FAP)-targeted peptide, attached to the chelating agent 1,4,7,10-tetraazacyclododecane-N,N',N",N'"-tetraacetic acid (DOTA), and radiolabeled with the beta-emitting radioisotope lutetium Lu 177, with potential antineoplastic activity. Upon administration of lutetium Lu 177-FAP-2286, the FAP-2286 moiety targets and binds to FAP-expressing cancer-associated fibroblasts (CAFs) and FAP-expressing tumor cells. Upon binding and internalization, this radioconjugate specifically delivers a cytotoxic dose of beta radiation to CAFs and tumor cells. FAP, a cell surface protein, is overexpressed on CAFs in the tumor microenvironment (TME) and certain tumor cells." @default.
- NCIT_C180806 NCIT_A7 NCIT_C17799 @default.
- NCIT_C180806 NCIT_NHC0 "C180806" @default.
- NCIT_C180806 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C180806 NCIT_P107 "Lutetium Lu 177-FAP-2286" @default.
- NCIT_C180806 NCIT_P108 "Lutetium Lu 177-FAP-2286" @default.
- NCIT_C180806 NCIT_P208 "CL1663486" @default.
- NCIT_C180806 NCIT_P322 "CTRP" @default.
- NCIT_C180806 normalizedInformationContent "100" @default.
- NCIT_C180806 referenceCount "1" @default.
- NCIT_C180806 hasExactSynonym "177Lu Labeled DOTA-conjugated Peptide FAP-2286" @default.
- NCIT_C180806 hasExactSynonym "177Lu-FAP-2286" @default.
- NCIT_C180806 hasExactSynonym "Lutetium Lu 177-FAP-2286" @default.
- NCIT_C180806 hasExactSynonym "Lutetium-177-FAP-2286" @default.
- NCIT_C180806 inSubset NCIT_C116977 @default.
- NCIT_C180806 inSubset NCIT_C116978 @default.
- NCIT_C180806 inSubset NCIT_C128784 @default.
- NCIT_C180806 inSubset NCIT_C176424 @default.
- NCIT_C180806 type Class @default.
- NCIT_C180806 isDefinedBy ncit.owl @default.
- NCIT_C180806 label "Lutetium Lu 177-FAP-2286" @default.
- NCIT_C180806 subClassOf NCIT_C1446 @default.
- NCIT_C180806 subClassOf NCIT_C1511 @default.
- NCIT_C180806 subClassOf NCIT_C1512 @default.
- NCIT_C180806 subClassOf NCIT_C180806 @default.
- NCIT_C180806 subClassOf NCIT_C1908 @default.
- NCIT_C180806 subClassOf NCIT_C1909 @default.
- NCIT_C180806 subClassOf NCIT_C2124 @default.
- NCIT_C180806 subClassOf NCIT_C307 @default.
- NCIT_C180806 subClassOf NCIT_C308 @default.