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- NCIT_C180825 IAO_0000115 "A T-cell redirecting agent and humanized immunoglobulin (Ig) G1 bispecific antibody targeting both human kallikrein-2 (hK2; KLK2) expressed on tumor cells and the CD3 receptor complex expressed on T-cells, with potential immunomodulating and antineoplastic activities. Upon subcutaneous administration, anti-KLK2/CD3 bispecific antibody JNJ-78278343 binds to both CD3 on T-cells and KLK2 on KLK2-expressing tumor cells. The resulting cross-linkage activates and redirects T-cells to KLK2-expressing tumor cells. This results in T-cell-mediated lysis of KLK2-expressing tumor cells. KLK2 is overexpressed in certain tumors, including prostate adenocarcinoma." @default.
- NCIT_C180825 NCIT_A7 NCIT_C18163 @default.
- NCIT_C180825 NCIT_NHC0 "C180825" @default.
- NCIT_C180825 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C180825 NCIT_P108 "Anti-KLK2/CD3 Bispecific Antibody JNJ-78278343" @default.
- NCIT_C180825 NCIT_P208 "CL1663476" @default.
- NCIT_C180825 NCIT_P322 "GDC" @default.
- NCIT_C180825 NCIT_P399 "805647" @default.
- NCIT_C180825 NCIT_R124 NCIT_C17710 @default.
- NCIT_C180825 NCIT_R124 NCIT_C17828 @default.
- NCIT_C180825 NCIT_R124 NCIT_C18219 @default.
- NCIT_C180825 NCIT_R124 NCIT_C19986 @default.
- NCIT_C180825 NCIT_R124 NCIT_C40474 @default.
- NCIT_C180825 normalizedInformationContent "100" @default.
- NCIT_C180825 referenceCount "1" @default.
- NCIT_C180825 hasExactSynonym "Anti-KLK2/CD3 Bispecific Antibody JNJ-78278343" @default.
- NCIT_C180825 hasExactSynonym "JNJ 78278343" @default.
- NCIT_C180825 hasExactSynonym "JNJ-78278343" @default.
- NCIT_C180825 hasExactSynonym "JNJ78278343" @default.
- NCIT_C180825 hasExactSynonym "T-cell Redirecting Agent JNJ-78278343" @default.
- NCIT_C180825 inSubset NCIT_C128784 @default.
- NCIT_C180825 inSubset NCIT_C157711 @default.
- NCIT_C180825 inSubset NCIT_C157712 @default.
- NCIT_C180825 inSubset NCIT_C176424 @default.
- NCIT_C180825 type Class @default.
- NCIT_C180825 isDefinedBy ncit.owl @default.
- NCIT_C180825 label "Anti-KLK2/CD3 Bispecific Antibody JNJ-78278343" @default.
- NCIT_C180825 subClassOf NCIT_C112883 @default.
- NCIT_C180825 subClassOf NCIT_C129821 @default.
- NCIT_C180825 subClassOf NCIT_C129822 @default.
- NCIT_C180825 subClassOf NCIT_C1454 @default.
- NCIT_C180825 subClassOf NCIT_C180825 @default.
- NCIT_C180825 subClassOf NCIT_C1908 @default.
- NCIT_C180825 subClassOf NCIT_C1909 @default.
- NCIT_C180825 subClassOf NCIT_C201282 @default.
- NCIT_C180825 subClassOf NCIT_C20401 @default.
- NCIT_C180825 subClassOf NCIT_C274 @default.
- NCIT_C180825 subClassOf NCIT_C28227 @default.
- NCIT_C180825 subClassOf NCIT_C307 @default.
- NCIT_C180825 subClassOf NCIT_C308 @default.