Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C180826> ?p ?o ?g. }
Showing items 1 to 33 of
33
with 100 items per page.
- NCIT_C180826 IAO_0000115 "An inhibitor of hypoxia inducible factor (HIF)-2alpha, with potential antineoplastic activity. Upon administration, HIF-2alpha inhibitor DFF332 targets and binds to HIF-2alpha, thereby preventing HIF-2alpha heterodimerization and its subsequent binding to DNA. This results in decreased transcription and expression of HIF-2alpha downstream target genes, many of which regulate tumor cell growth and survival. Blocking HIF-2alpha reduces the proliferation of HIF-2alpha-expressing tumor cells. HIF-2alpha, a heterodimeric transcription factor overexpressed in many cancer cell types, promotes proliferation, progression and metastasis of tumors." @default.
- NCIT_C180826 NCIT_A7 NCIT_C104306 @default.
- NCIT_C180826 NCIT_NHC0 "C180826" @default.
- NCIT_C180826 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C180826 NCIT_P107 "HIF2alpha Inhibitor DFF332" @default.
- NCIT_C180826 NCIT_P108 "HIF2alpha Inhibitor DFF332" @default.
- NCIT_C180826 NCIT_P208 "CL1663477" @default.
- NCIT_C180826 NCIT_P322 "CTRP" @default.
- NCIT_C180826 NCIT_P322 "GDC" @default.
- NCIT_C180826 NCIT_P399 "805645" @default.
- NCIT_C180826 normalizedInformationContent "100" @default.
- NCIT_C180826 referenceCount "1" @default.
- NCIT_C180826 hasExactSynonym "DFF 332" @default.
- NCIT_C180826 hasExactSynonym "DFF-332" @default.
- NCIT_C180826 hasExactSynonym "DFF332" @default.
- NCIT_C180826 hasExactSynonym "HIF-2a Inhibitor DFF332" @default.
- NCIT_C180826 hasExactSynonym "HIF2alpha Inhibitor DFF332" @default.
- NCIT_C180826 inSubset NCIT_C116977 @default.
- NCIT_C180826 inSubset NCIT_C116978 @default.
- NCIT_C180826 inSubset NCIT_C128784 @default.
- NCIT_C180826 inSubset NCIT_C157711 @default.
- NCIT_C180826 inSubset NCIT_C157712 @default.
- NCIT_C180826 inSubset NCIT_C176424 @default.
- NCIT_C180826 type Class @default.
- NCIT_C180826 isDefinedBy ncit.owl @default.
- NCIT_C180826 label "HIF2alpha Inhibitor DFF332" @default.
- NCIT_C180826 subClassOf NCIT_C129824 @default.
- NCIT_C180826 subClassOf NCIT_C180826 @default.
- NCIT_C180826 subClassOf NCIT_C1908 @default.
- NCIT_C180826 subClassOf NCIT_C1909 @default.
- NCIT_C180826 subClassOf NCIT_C192728 @default.
- NCIT_C180826 subClassOf NCIT_C2189 @default.
- NCIT_C180826 subClassOf NCIT_C274 @default.