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- NCIT_C180828 IAO_0000115 "A monoclonal antibody directed against the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CLDN18.2 monoclonal antibody M108 specifically targets, binds to and inhibits CLDN18.2 expressed on tumor cells. The binding induces antibody-dependent cellular cytotoxicity (ADCC) and may kill CLDN18.2-expressing tumor cells and inhibit cell proliferation. CLDN18.2, a tight junction protein and stomach-specific isoform of claudin-18, is expressed on a variety of tumor cells. Its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa." @default.
- NCIT_C180828 NCIT_A7 NCIT_C150412 @default.
- NCIT_C180828 NCIT_NHC0 "C180828" @default.
- NCIT_C180828 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C180828 NCIT_P108 "Anti-claudin 18.2 Monoclonal Antibody M108" @default.
- NCIT_C180828 NCIT_P208 "CL1663463" @default.
- NCIT_C180828 NCIT_P210 "15589-31-8" @default.
- NCIT_C180828 NCIT_P319 "6THJ337EJ9" @default.
- NCIT_C180828 NCIT_P322 "FDA" @default.
- NCIT_C180828 NCIT_P322 "GDC" @default.
- NCIT_C180828 NCIT_P399 "805604" @default.
- NCIT_C180828 NCIT_R124 NCIT_C17710 @default.
- NCIT_C180828 NCIT_R124 NCIT_C17828 @default.
- NCIT_C180828 NCIT_R124 NCIT_C18219 @default.
- NCIT_C180828 NCIT_R124 NCIT_C19986 @default.
- NCIT_C180828 NCIT_R124 NCIT_C40474 @default.
- NCIT_C180828 normalizedInformationContent "100" @default.
- NCIT_C180828 referenceCount "1" @default.
- NCIT_C180828 hasExactSynonym "Anti-CLDN18.2 Monoclonal Antibody M108" @default.
- NCIT_C180828 hasExactSynonym "Anti-claudin 18.2 Monoclonal Antibody M108" @default.
- NCIT_C180828 hasExactSynonym "M 108" @default.
- NCIT_C180828 hasExactSynonym "M-108" @default.
- NCIT_C180828 hasExactSynonym "M108" @default.
- NCIT_C180828 hasExactSynonym "TERALLETHRIN" @default.
- NCIT_C180828 inSubset NCIT_C128784 @default.
- NCIT_C180828 inSubset NCIT_C157711 @default.
- NCIT_C180828 inSubset NCIT_C157712 @default.
- NCIT_C180828 inSubset NCIT_C176424 @default.
- NCIT_C180828 inSubset NCIT_C63923 @default.
- NCIT_C180828 type Class @default.
- NCIT_C180828 isDefinedBy ncit.owl @default.
- NCIT_C180828 label "Anti-claudin 18.2 Monoclonal Antibody M108" @default.
- NCIT_C180828 subClassOf NCIT_C129821 @default.
- NCIT_C180828 subClassOf NCIT_C129822 @default.
- NCIT_C180828 subClassOf NCIT_C163758 @default.
- NCIT_C180828 subClassOf NCIT_C179676 @default.
- NCIT_C180828 subClassOf NCIT_C180828 @default.
- NCIT_C180828 subClassOf NCIT_C1908 @default.
- NCIT_C180828 subClassOf NCIT_C1909 @default.
- NCIT_C180828 subClassOf NCIT_C200250 @default.
- NCIT_C180828 subClassOf NCIT_C20401 @default.
- NCIT_C180828 subClassOf NCIT_C274 @default.
- NCIT_C180828 subClassOf NCIT_C307 @default.
- NCIT_C180828 subClassOf NCIT_C308 @default.