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- NCIT_C180830 IAO_0000115 "A human monoclonal antibody targeting leukocyte surface antigen CD47, with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-CD47 monoclonal antibody STI-6643 targets and binds to CD47 expressed on tumor cells, blocking the interaction of CD47 with signal regulatory protein alpha (SIRPa) expressed on phagocytic cells. This prevents CD47/SIRPa-mediated signaling and abrogates the CD47/SIRPa-mediated inhibition of macrophage activation and phagocytosis of cancer cells. This induces pro-phagocytic signaling mediated by the binding of calreticulin (CRT), which is specifically expressed on the surface of tumor cells, to low-density lipoprotein (LDL) receptor-related protein-1 (LRP-1), which is expressed on macrophages, and results in macrophage activation and the specific phagocytosis of tumor cells. CD47, also called integrin-associated protein (IAP), is a tumor-associated antigen (TAA) expressed on normal, healthy hematopoietic stem cells (HSCs) but is overexpressed on the surface of a variety of cancer cells and contributes to poor prognosis. Expression of CD47, and its interaction with SIRPa, leads to the inhibition of macrophage activation and protects cancer cells from phagocytosis, thereby allowing cancer cells to proliferate. Compared to other anti-CD47 monoclonal antibodies, STI-6643 shows decreased binding to red blood cells (RBCs). This may prevent adverse effects such as anemia that can result from the blockade of CD47 expressed on RBCs. In addition, STI-6643 has a minimal effect on T-, B- or natural killer (NK) cell depletion which may further improve its efficacy by preserving infiltrating anti-tumor immune cells." @default.
- NCIT_C180830 NCIT_A7 NCIT_C25795 @default.
- NCIT_C180830 NCIT_NHC0 "C180830" @default.
- NCIT_C180830 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C180830 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C180830 NCIT_P108 "Anti-CD47 Monoclonal Antibody STI-6643" @default.
- NCIT_C180830 NCIT_P208 "CL1663465" @default.
- NCIT_C180830 NCIT_P210 "2376730-61-7" @default.
- NCIT_C180830 NCIT_P319 "68SNC9B4YR" @default.
- NCIT_C180830 NCIT_P322 "FDA" @default.
- NCIT_C180830 NCIT_P322 "GDC" @default.
- NCIT_C180830 NCIT_P399 "805635" @default.
- NCIT_C180830 NCIT_R124 NCIT_C17710 @default.
- NCIT_C180830 NCIT_R124 NCIT_C17828 @default.
- NCIT_C180830 NCIT_R124 NCIT_C18219 @default.
- NCIT_C180830 NCIT_R124 NCIT_C19986 @default.
- NCIT_C180830 NCIT_R124 NCIT_C40474 @default.
- NCIT_C180830 normalizedInformationContent "100" @default.
- NCIT_C180830 referenceCount "1" @default.
- NCIT_C180830 hasExactSynonym "Anti-CD47 Monoclonal Antibody STI-6643" @default.
- NCIT_C180830 hasExactSynonym "STI 6643" @default.
- NCIT_C180830 hasExactSynonym "STI-6643" @default.
- NCIT_C180830 hasExactSynonym "STI6643" @default.
- NCIT_C180830 inSubset NCIT_C128784 @default.
- NCIT_C180830 inSubset NCIT_C157711 @default.
- NCIT_C180830 inSubset NCIT_C157712 @default.
- NCIT_C180830 inSubset NCIT_C176424 @default.
- NCIT_C180830 inSubset NCIT_C63923 @default.
- NCIT_C180830 type Class @default.
- NCIT_C180830 isDefinedBy ncit.owl @default.
- NCIT_C180830 label "Anti-CD47 Monoclonal Antibody STI-6643" @default.
- NCIT_C180830 subClassOf B44667bd8146d85197cc45bce0d22ebb5 @default.
- NCIT_C180830 subClassOf B877e01f2e6ac212829c00bf2f7a20018 @default.
- NCIT_C180830 subClassOf NCIT_C129821 @default.
- NCIT_C180830 subClassOf NCIT_C129822 @default.
- NCIT_C180830 subClassOf NCIT_C159583 @default.
- NCIT_C180830 subClassOf NCIT_C163758 @default.
- NCIT_C180830 subClassOf NCIT_C180830 @default.
- NCIT_C180830 subClassOf NCIT_C1908 @default.
- NCIT_C180830 subClassOf NCIT_C1909 @default.
- NCIT_C180830 subClassOf NCIT_C192655 @default.
- NCIT_C180830 subClassOf NCIT_C20401 @default.
- NCIT_C180830 subClassOf NCIT_C274 @default.
- NCIT_C180830 subClassOf NCIT_C307 @default.
- NCIT_C180830 subClassOf NCIT_C308 @default.