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- NCIT_C180834 IAO_0000115 "An orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1; IDH-1; IDH1 [NADP+] soluble) mutant forms, with potential antineoplastic activity. Upon administration, IDH1 inhibitor KY100001 specifically binds to and inhibits certain mutant forms of IDH1, thereby inhibiting the formation of the oncometabolite 2-hydroxyglutarate (2HG) from alpha-ketoglutarate (a-KG). This prevents 2HG-mediated signaling and leads to both an induction of cellular differentiation and an inhibition of cellular proliferation in tumor cells expressing IDH1 mutations. IDH1 mutations are highly expressed in certain malignancies; they initiate and drive cancer growth by both blocking cell differentiation and catalyzing the formation of 2HG." @default.
- NCIT_C180834 NCIT_A7 NCIT_C77217 @default.
- NCIT_C180834 NCIT_NHC0 "C180834" @default.
- NCIT_C180834 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C180834 NCIT_P108 "IDH1 Inhibitor KY100001" @default.
- NCIT_C180834 NCIT_P208 "CL1663469" @default.
- NCIT_C180834 NCIT_P322 "GDC" @default.
- NCIT_C180834 NCIT_P399 "805642" @default.
- NCIT_C180834 normalizedInformationContent "100" @default.
- NCIT_C180834 referenceCount "1" @default.
- NCIT_C180834 hasExactSynonym "IDH1 Inhibitor KY100001" @default.
- NCIT_C180834 hasExactSynonym "KY 100001" @default.
- NCIT_C180834 hasExactSynonym "KY-100001" @default.
- NCIT_C180834 hasExactSynonym "KY100001" @default.
- NCIT_C180834 hasExactSynonym "Mutant IDH1 Inhibitor KY100001" @default.
- NCIT_C180834 hasExactSynonym "Mutant-selective IDH1 Inhibitor KY100001" @default.
- NCIT_C180834 inSubset NCIT_C128784 @default.
- NCIT_C180834 inSubset NCIT_C157711 @default.
- NCIT_C180834 inSubset NCIT_C157712 @default.
- NCIT_C180834 inSubset NCIT_C176424 @default.
- NCIT_C180834 type Class @default.
- NCIT_C180834 isDefinedBy ncit.owl @default.
- NCIT_C180834 label "IDH1 Inhibitor KY100001" @default.
- NCIT_C180834 subClassOf NCIT_C129824 @default.
- NCIT_C180834 subClassOf NCIT_C129825 @default.
- NCIT_C180834 subClassOf NCIT_C137826 @default.
- NCIT_C180834 subClassOf NCIT_C163758 @default.
- NCIT_C180834 subClassOf NCIT_C168618 @default.
- NCIT_C180834 subClassOf NCIT_C180834 @default.
- NCIT_C180834 subClassOf NCIT_C1908 @default.
- NCIT_C180834 subClassOf NCIT_C1909 @default.
- NCIT_C180834 subClassOf NCIT_C2189 @default.
- NCIT_C180834 subClassOf NCIT_C274 @default.
- NCIT_C180834 subClassOf NCIT_C471 @default.