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- NCIT_C180836 IAO_0000115 "A bispecific antibody and T-cell engager composed of two single chain variable fragments (bi-scFvs) directed against both a mutant form of the human epidermal growth factor receptor (EGFR), EGFR variant III (EGFRvIII), and the epsilon subunit of the human T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. Upon administration, anti-EGFRvIII/CD3 bispecific antibody hEGFRvIII:CD3 bi-scFv specifically binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and hEGFRvIII on hEGFRvIII-expressing tumor cells. This crosslinks T-cells and tumor cells, and activates and redirects CTLs to hEGFRvIII-expressing tumor cells. This leads to CTL-mediated killing of hEGFRvIII-expressing tumor cells. hEGFRvIII, a mutant form of EGFR expressed in certain tumor cell types and frequently seen in malignant glioma, plays a key role in tumor cell proliferation and survival." @default.
- NCIT_C180836 NCIT_A7 NCIT_C101140 @default.
- NCIT_C180836 NCIT_NHC0 "C180836" @default.
- NCIT_C180836 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C180836 NCIT_P108 "Anti-EGFRvIII/CD3 Bispecific Antibody hEGFRvIII:CD3 bi-scFv" @default.
- NCIT_C180836 NCIT_P208 "CL1663459" @default.
- NCIT_C180836 NCIT_P322 "GDC" @default.
- NCIT_C180836 NCIT_P399 "805646" @default.
- NCIT_C180836 NCIT_R124 NCIT_C17710 @default.
- NCIT_C180836 NCIT_R124 NCIT_C17828 @default.
- NCIT_C180836 NCIT_R124 NCIT_C18219 @default.
- NCIT_C180836 NCIT_R124 NCIT_C19986 @default.
- NCIT_C180836 NCIT_R124 NCIT_C40474 @default.
- NCIT_C180836 normalizedInformationContent "100" @default.
- NCIT_C180836 referenceCount "1" @default.
- NCIT_C180836 hasExactSynonym "Anti-EGFRvIII/CD3 Bispecific Antibody hEGFRvIII:CD3 bi-scFv" @default.
- NCIT_C180836 hasExactSynonym "BRiTE" @default.
- NCIT_C180836 hasExactSynonym "hEGFRvIII-CD3-bi-scFv Bispecific T-cell Engager" @default.
- NCIT_C180836 hasExactSynonym "hEGFRvIII:CD3 bi-scFv" @default.
- NCIT_C180836 inSubset NCIT_C128784 @default.
- NCIT_C180836 inSubset NCIT_C157711 @default.
- NCIT_C180836 inSubset NCIT_C157712 @default.
- NCIT_C180836 inSubset NCIT_C176424 @default.
- NCIT_C180836 type Class @default.
- NCIT_C180836 isDefinedBy ncit.owl @default.
- NCIT_C180836 label "Anti-EGFRvIII/CD3 Bispecific Antibody hEGFRvIII:CD3 bi-scFv" @default.
- NCIT_C180836 subClassOf NCIT_C112883 @default.
- NCIT_C180836 subClassOf NCIT_C129821 @default.
- NCIT_C180836 subClassOf NCIT_C129822 @default.
- NCIT_C180836 subClassOf NCIT_C1454 @default.
- NCIT_C180836 subClassOf NCIT_C180836 @default.
- NCIT_C180836 subClassOf NCIT_C1908 @default.
- NCIT_C180836 subClassOf NCIT_C1909 @default.
- NCIT_C180836 subClassOf NCIT_C201282 @default.
- NCIT_C180836 subClassOf NCIT_C20401 @default.
- NCIT_C180836 subClassOf NCIT_C274 @default.
- NCIT_C180836 subClassOf NCIT_C28227 @default.
- NCIT_C180836 subClassOf NCIT_C307 @default.
- NCIT_C180836 subClassOf NCIT_C308 @default.