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- NCIT_C180865 IAO_0000115 "A conjugate composed of a pH low insertion peptide (pHLIP) linked to the camptothecin analog exatecan, with potential antineoplastic activity. Upon administration of pHLIP-exatecan conjugate CBX-12, the pHLIP moiety specifically targets and gets inserted into the cellular membrane of tumor cells in environments with low extracellular pH. Then the exatecan moiety is released intracellularly via glutathione reduction of the linker. Exatecan inhibits DNA topoisomerase I activity, thereby inhibiting DNA replication and resulting in cell cycle arrest and tumor cell apoptosis. Tumor cell environments are more acidic than normal, healthy tissue environments. The pHLIP forms an alpha helix and becomes inserted across the cell membrane specifically at the low extracellular pH found within tumors." @default.
- NCIT_C180865 NCIT_A7 NCIT_C16516 @default.
- NCIT_C180865 NCIT_NHC0 "C180865" @default.
- NCIT_C180865 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C180865 NCIT_P107 "pH Low Insertion Peptide-exatecan Conjugate CBX-12" @default.
- NCIT_C180865 NCIT_P108 "pH Low Insertion Peptide-exatecan Conjugate CBX-12" @default.
- NCIT_C180865 NCIT_P208 "CL1663446" @default.
- NCIT_C180865 NCIT_P322 "CTRP" @default.
- NCIT_C180865 NCIT_P322 "GDC" @default.
- NCIT_C180865 NCIT_P399 "805773" @default.
- NCIT_C180865 normalizedInformationContent "100" @default.
- NCIT_C180865 referenceCount "1" @default.
- NCIT_C180865 hasExactSynonym "Alphalex Conjugate CBX-12" @default.
- NCIT_C180865 hasExactSynonym "Alphalex-exatecan Conjugate CBX-12" @default.
- NCIT_C180865 hasExactSynonym "CBX 12" @default.
- NCIT_C180865 hasExactSynonym "CBX-12" @default.
- NCIT_C180865 hasExactSynonym "CBX12" @default.
- NCIT_C180865 hasExactSynonym "Low pH Targeting Alphalex-exatecan Conjugate CBX-12" @default.
- NCIT_C180865 hasExactSynonym "pH Low Insertion Peptide-exatecan Conjugate CBX-12" @default.
- NCIT_C180865 hasExactSynonym "pHLIP-exatecan Conjugate CBX-12" @default.
- NCIT_C180865 inSubset NCIT_C116977 @default.
- NCIT_C180865 inSubset NCIT_C116978 @default.
- NCIT_C180865 inSubset NCIT_C128784 @default.
- NCIT_C180865 inSubset NCIT_C157711 @default.
- NCIT_C180865 inSubset NCIT_C157712 @default.
- NCIT_C180865 inSubset NCIT_C176424 @default.
- NCIT_C180865 type Class @default.
- NCIT_C180865 isDefinedBy ncit.owl @default.
- NCIT_C180865 label "pH Low Insertion Peptide-exatecan Conjugate CBX-12" @default.
- NCIT_C180865 subClassOf NCIT_C129824 @default.
- NCIT_C180865 subClassOf NCIT_C129825 @default.
- NCIT_C180865 subClassOf NCIT_C1748 @default.
- NCIT_C180865 subClassOf NCIT_C180865 @default.
- NCIT_C180865 subClassOf NCIT_C1904 @default.
- NCIT_C180865 subClassOf NCIT_C1908 @default.
- NCIT_C180865 subClassOf NCIT_C1909 @default.
- NCIT_C180865 subClassOf NCIT_C2189 @default.
- NCIT_C180865 subClassOf NCIT_C274 @default.
- NCIT_C180865 subClassOf NCIT_C2843 @default.
- NCIT_C180865 subClassOf NCIT_C471 @default.