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- NCIT_C180866 IAO_0000115 "A bispecific antibody targeting both the human cell surface antigen CD47 and the immunosuppressive ligand human programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274), with potential immunostimulating, phagocytosis-inducing and antineoplastic activities. Upon administration, anti-CD47/anti-PD-L1 bispecific antibody PF-07257876 targets and binds to both CD47 and PD-L1 expressed on tumor cells. The CD47 binding by PF-07257876 blocks the interaction of CD47 with signal regulatory protein alpha (SIRPalpha), an inhibitory protein expressed on macrophages and dendritic cells (DCs), which prevents CD47/SIRPalpha-mediated signaling and abrogates the CD47/SIRPalpha-mediated inhibition of phagocytosis. This induces pro-phagocytic signaling mediated by the binding of calreticulin (CRT), specifically expressed on the surface of tumor cells, to low-density lipoprotein (LDL) receptor-related protein (LRP), expressed on macrophages, and results in macrophage activation and the specific phagocytosis of CD47-expressing tumor cells. The binding of PF-07257876 to PD-L1 blocks its binding to and activation of its receptor, programmed cell death 1 (PD-1; cluster of differentiation 279; CD279). This reverses T-cell inactivation caused by PD-1/PD-L1 signaling and enhances the cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune response against PD-L1-expressing tumor cells. CD47, also called integrin-associated protein (IAP), is a tumor-associated antigen (TAA) widely expressed on normal, healthy cells, such as red blood cells and platelets, and overexpressed on the surface of a variety of cancer cells. Expression of CD47, and its interaction with SIRPalpha, leads to the inhibition of macrophage activation, which protects cancer cells from phagocytosis and allows proliferation of cancer cells. PD-L1 is overexpressed by many human cancer cell types. PD-L1 binding to PD-1, a transmembrane protein belonging to the immunoglobulin superfamily (IgSF) that is expressed on activated T-cells, suppresses the immune system and results in immune evasion. By co-targeting CD47 and PD-L1, PF-07257876 may more selectively bind to tumor cells expressing both CD47 and PD-L1, reducing the side effects caused by the blockade of CD47 expressed on healthy hematopoietic stem cells (HSCs)." @default.
- NCIT_C180866 NCIT_A7 NCIT_C25795 @default.
- NCIT_C180866 NCIT_A7 NCIT_C96024 @default.
- NCIT_C180866 NCIT_NHC0 "C180866" @default.
- NCIT_C180866 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C180866 NCIT_P107 "Anti-CD47/Anti-PD-L1 Bispecific Antibody PF-07257876" @default.
- NCIT_C180866 NCIT_P108 "Anti-CD47/Anti-PD-L1 Bispecific Antibody PF-07257876" @default.
- NCIT_C180866 NCIT_P208 "CL1663447" @default.
- NCIT_C180866 NCIT_P322 "CTRP" @default.
- NCIT_C180866 NCIT_P322 "GDC" @default.
- NCIT_C180866 NCIT_P399 "810710" @default.
- NCIT_C180866 NCIT_R124 NCIT_C17710 @default.
- NCIT_C180866 NCIT_R124 NCIT_C17828 @default.
- NCIT_C180866 NCIT_R124 NCIT_C18219 @default.
- NCIT_C180866 NCIT_R124 NCIT_C19986 @default.
- NCIT_C180866 NCIT_R124 NCIT_C40474 @default.
- NCIT_C180866 normalizedInformationContent "100" @default.
- NCIT_C180866 referenceCount "1" @default.
- NCIT_C180866 hasExactSynonym "Anti-CD47/Anti-PD-L1 Bispecific Antibody PF-07257876" @default.
- NCIT_C180866 hasExactSynonym "Anti-CD47/PD-L1 Bispecific Antibody PF-07257876" @default.
- NCIT_C180866 hasExactSynonym "CD47 x PD-L1 Bispecific Antibody PF-07257876" @default.
- NCIT_C180866 hasExactSynonym "CD47-PD-L1 Bispecific Antibody PF-07257876" @default.
- NCIT_C180866 hasExactSynonym "PF 07257876" @default.
- NCIT_C180866 hasExactSynonym "PF-07257876" @default.
- NCIT_C180866 hasExactSynonym "PF07257876" @default.
- NCIT_C180866 inSubset NCIT_C116977 @default.
- NCIT_C180866 inSubset NCIT_C116978 @default.
- NCIT_C180866 inSubset NCIT_C128784 @default.
- NCIT_C180866 inSubset NCIT_C157711 @default.
- NCIT_C180866 inSubset NCIT_C157712 @default.
- NCIT_C180866 inSubset NCIT_C176424 @default.
- NCIT_C180866 type Class @default.
- NCIT_C180866 isDefinedBy ncit.owl @default.
- NCIT_C180866 label "Anti-CD47/Anti-PD-L1 Bispecific Antibody PF-07257876" @default.
- NCIT_C180866 subClassOf NCIT_C128057 @default.
- NCIT_C180866 subClassOf NCIT_C129821 @default.
- NCIT_C180866 subClassOf NCIT_C129822 @default.
- NCIT_C180866 subClassOf NCIT_C141144 @default.
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- NCIT_C180866 subClassOf NCIT_C163758 @default.
- NCIT_C180866 subClassOf NCIT_C180866 @default.
- NCIT_C180866 subClassOf NCIT_C1908 @default.
- NCIT_C180866 subClassOf NCIT_C1909 @default.
- NCIT_C180866 subClassOf NCIT_C191689 @default.
- NCIT_C180866 subClassOf NCIT_C192655 @default.
- NCIT_C180866 subClassOf NCIT_C20401 @default.
- NCIT_C180866 subClassOf NCIT_C274 @default.
- NCIT_C180866 subClassOf NCIT_C307 @default.
- NCIT_C180866 subClassOf NCIT_C308 @default.