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- NCIT_C180884 IAO_0000115 "A bispecific antibody composed of a human, Fc-silenced immunoglobulin G1 (IgG1) monoclonal antibody targeting the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18) fused with a single chain variable fragment (scFv) targeting 4-1BB (CD137; tumor necrosis factor receptor superfamily member 9; TNFRSF9), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CLDN18.2/anti-4-1BB bispecific antibody TJ-CD4B simultaneously targets and binds to CLDN18.2 expressed on tumor cells and 4-1BB expressed on a variety of leukocyte subsets including activated T-lymphocytes. Upon CLDN18.2 binding, the 4-1BB activation signal is induced and TJ-CD4B acts as a conditional 4-1BB agonist in the tumor microenvironment (TME), resulting in T-cell co-stimulation and T-lymphocyte-mediated anti-tumor activity. CLDN18.2, a tight junction protein and stomach-specific isoform of claudin-18, is expressed on a variety of tumor cells. Its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa. 4-1BB, a surface glycoprotein of the tumor necrosis factor receptor superfamily, is an inducible costimulatory receptor that plays a key role in T-cell proliferation, survival and cytolytic activity." @default.
- NCIT_C180884 NCIT_A7 NCIT_C150412 @default.
- NCIT_C180884 NCIT_NHC0 "C180884" @default.
- NCIT_C180884 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C180884 NCIT_P107 "Anti-claudin18.2/Anti-4-1BB Bispecific Antibody TJ-CD4B" @default.
- NCIT_C180884 NCIT_P108 "Anti-claudin18.2/Anti-4-1BB Bispecific Antibody TJ-CD4B" @default.
- NCIT_C180884 NCIT_P208 "CL1663495" @default.
- NCIT_C180884 NCIT_P322 "CTRP" @default.
- NCIT_C180884 NCIT_P322 "GDC" @default.
- NCIT_C180884 NCIT_P399 "805770" @default.
- NCIT_C180884 NCIT_R124 NCIT_C17710 @default.
- NCIT_C180884 NCIT_R124 NCIT_C17828 @default.
- NCIT_C180884 NCIT_R124 NCIT_C18219 @default.
- NCIT_C180884 NCIT_R124 NCIT_C19986 @default.
- NCIT_C180884 NCIT_R124 NCIT_C40474 @default.
- NCIT_C180884 normalizedInformationContent "100" @default.
- NCIT_C180884 referenceCount "1" @default.
- NCIT_C180884 hasExactSynonym "ABL111" @default.
- NCIT_C180884 hasExactSynonym "Anti-CLDN18.2/Anti-4-1BB Bispecific Antibody TJ-CD4B" @default.
- NCIT_C180884 hasExactSynonym "Anti-claudin18.2/4-1BB Bispecific Antibody TJ-CD4B" @default.
- NCIT_C180884 hasExactSynonym "Anti-claudin18.2/Anti-4-1BB Bispecific Antibody TJ-CD4B" @default.
- NCIT_C180884 hasExactSynonym "CLDN18.2 x 4-1BB BsAb TJ-CD4B" @default.
- NCIT_C180884 hasExactSynonym "CLDN18.2-4-1BB Bispecific Antibody TJ-CD4B" @default.
- NCIT_C180884 hasExactSynonym "TJ-CD4B" @default.
- NCIT_C180884 hasExactSynonym "TJ033721" @default.
- NCIT_C180884 inSubset NCIT_C116977 @default.
- NCIT_C180884 inSubset NCIT_C116978 @default.
- NCIT_C180884 inSubset NCIT_C128784 @default.
- NCIT_C180884 inSubset NCIT_C157711 @default.
- NCIT_C180884 inSubset NCIT_C157712 @default.
- NCIT_C180884 inSubset NCIT_C176424 @default.
- NCIT_C180884 type Class @default.
- NCIT_C180884 isDefinedBy ncit.owl @default.
- NCIT_C180884 label "Anti-claudin18.2/Anti-4-1BB Bispecific Antibody TJ-CD4B" @default.
- NCIT_C180884 subClassOf NCIT_C129821 @default.
- NCIT_C180884 subClassOf NCIT_C129822 @default.
- NCIT_C180884 subClassOf NCIT_C1454 @default.
- NCIT_C180884 subClassOf NCIT_C163758 @default.
- NCIT_C180884 subClassOf NCIT_C179676 @default.
- NCIT_C180884 subClassOf NCIT_C180884 @default.
- NCIT_C180884 subClassOf NCIT_C1908 @default.
- NCIT_C180884 subClassOf NCIT_C1909 @default.
- NCIT_C180884 subClassOf NCIT_C200250 @default.
- NCIT_C180884 subClassOf NCIT_C20401 @default.
- NCIT_C180884 subClassOf NCIT_C274 @default.
- NCIT_C180884 subClassOf NCIT_C307 @default.
- NCIT_C180884 subClassOf NCIT_C308 @default.