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- NCIT_C180889 IAO_0000115 "An agonistic antibody targeting the human cell surface glycoprotein CD226 (DNAX accessory molecule-1; DNAM-1), with potential immunostimulatory and antineoplastic activities. Upon administration, anti-CD226 agonist antibody LY3435151 targets and binds to CD226 on a variety of immune cell types, including T-cells, natural killer (NK) cells, B-cells and monocytes. This induces CD226-dependent signaling pathways, which may trigger the activation of antigen-presenting cells (APCs) and activate T-cells and NK cells. This may result in an enhanced cytotoxic T-lymphocyte (CTL)-mediated and NK cell-mediated immune response against tumor cells. CD226, a cell surface glycoprotein that functions as an adhesion molecule, is expressed on various immune cells and plays an important role in the co-activation of T-cells and NK cells upon interaction with its ligands CD155 and CD112." @default.
- NCIT_C180889 NCIT_A7 NCIT_C104067 @default.
- NCIT_C180889 NCIT_NHC0 "C180889" @default.
- NCIT_C180889 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C180889 NCIT_P107 "Anti-CD226 Agonist Antibody LY3435151" @default.
- NCIT_C180889 NCIT_P108 "Anti-CD226 Agonist Antibody LY3435151" @default.
- NCIT_C180889 NCIT_P208 "CL1663658" @default.
- NCIT_C180889 NCIT_P322 "CTRP" @default.
- NCIT_C180889 NCIT_P322 "GDC" @default.
- NCIT_C180889 NCIT_P399 "806251" @default.
- NCIT_C180889 normalizedInformationContent "100" @default.
- NCIT_C180889 referenceCount "1" @default.
- NCIT_C180889 hasExactSynonym "Anti-CD226 Agonist Antibody LY3435151" @default.
- NCIT_C180889 hasExactSynonym "Anti-CD226 Agonistic Antibody LY3435151" @default.
- NCIT_C180889 hasExactSynonym "Anti-DNAM-1 Agonist Antibody LY3435151" @default.
- NCIT_C180889 hasExactSynonym "LY 3435151" @default.
- NCIT_C180889 hasExactSynonym "LY-3435151" @default.
- NCIT_C180889 hasExactSynonym "LY3435151" @default.
- NCIT_C180889 inSubset NCIT_C116977 @default.
- NCIT_C180889 inSubset NCIT_C116978 @default.
- NCIT_C180889 inSubset NCIT_C128784 @default.
- NCIT_C180889 inSubset NCIT_C157711 @default.
- NCIT_C180889 inSubset NCIT_C157712 @default.
- NCIT_C180889 inSubset NCIT_C176424 @default.
- NCIT_C180889 type Class @default.
- NCIT_C180889 isDefinedBy ncit.owl @default.
- NCIT_C180889 label "Anti-CD226 Agonist Antibody LY3435151" @default.
- NCIT_C180889 subClassOf NCIT_C129821 @default.
- NCIT_C180889 subClassOf NCIT_C129822 @default.
- NCIT_C180889 subClassOf NCIT_C180889 @default.
- NCIT_C180889 subClassOf NCIT_C1908 @default.
- NCIT_C180889 subClassOf NCIT_C1909 @default.
- NCIT_C180889 subClassOf NCIT_C274 @default.
- NCIT_C180889 subClassOf NCIT_C307 @default.