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- NCIT_C180911 IAO_0000115 "An inhaled formulation of the endogenous cytokine human interferon (IFN) beta-1a, with potential antiviral and immunomodulating activities. Administrated through inhalation of the nebulized solution, SNG001 targets and binds to specific type I IFN receptors, which eventually results in the transcription and translation of genes containing an interferon-specific response element and leads to the production of various anti-viral proteins and modulates the production of various immune-modulating proteins. This reduces the production of certain pro-inflammatory cytokines while upregulating the anti-inflammatory cytokine interleukin 10 (IL-10), upregulates the expression of major histocompatibility (MHC) I proteins which allows for increased presentation of peptides derived from viral antigens, and activates CD8+ T cells as well as other immune cells. Endogenous IFN-beta-1a is produced following viral infection and it plays a key role in innate immune response against viral pathogens." @default.
- NCIT_C180911 NCIT_NHC0 "C180911" @default.
- NCIT_C180911 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C180911 NCIT_P108 "Interferon Beta-1a Inhalation Solution SNG001" @default.
- NCIT_C180911 NCIT_P208 "CL1663649" @default.
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- NCIT_C180911 NCIT_R146 NCIT_C37274 @default.
- NCIT_C180911 normalizedInformationContent "100" @default.
- NCIT_C180911 referenceCount "1" @default.
- NCIT_C180911 hasExactSynonym "Interferon Beta-1a Inhalation Solution SNG001" @default.
- NCIT_C180911 hasExactSynonym "SNG 001" @default.
- NCIT_C180911 hasExactSynonym "SNG-001" @default.
- NCIT_C180911 hasExactSynonym "SNG001" @default.
- NCIT_C180911 inSubset NCIT_C173381 @default.
- NCIT_C180911 inSubset NCIT_C173383 @default.
- NCIT_C180911 type Class @default.
- NCIT_C180911 isDefinedBy ncit.owl @default.
- NCIT_C180911 label "Interferon Beta-1a Inhalation Solution SNG001" @default.
- NCIT_C180911 subClassOf NCIT_C1283 @default.
- NCIT_C180911 subClassOf NCIT_C180911 @default.
- NCIT_C180911 subClassOf NCIT_C1908 @default.
- NCIT_C180911 subClassOf NCIT_C1909 @default.
- NCIT_C180911 subClassOf NCIT_C307 @default.
- NCIT_C180911 subClassOf NCIT_C308 @default.
- NCIT_C180911 subClassOf NCIT_C495 @default.
- NCIT_C180911 subClassOf NCIT_C584 @default.