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- NCIT_C180912 IAO_0000115 "A combination of two human immunoglobulin G1 (IgG1) monoclonal antibodies C135-LS and C144-LS directed against the spike protein (SP) of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), that are isolated from convalescent patients with SARS-CoV-2 infection and engineered with a mutation to prolong their half-lives, that can potentially be used for immunization against COVID-19. Upon administration, anti-SARS-CoV-2 monoclonal antibodies C135-LS/C144-LS specifically target and bind to two distinct epitopes on the receptor-binding domain (RBD) of SP, thereby blocking viral attachment and entry into human cells and may thereby neutralize SARS-CoV-2. This may slow the progression of the disease and accelerate recovery, and may potentially provide temporary protection against infection with SARS-CoV-2. Binding to two distinct regions of the RBD of SP may decrease the potential for virus escape mutants that occur upon treatment with a single SARS-CoV-2 antibody, and may provide enhanced protection against loss of efficacy." @default.
- NCIT_C180912 NCIT_A7 NCIT_C178209 @default.
- NCIT_C180912 NCIT_NHC0 "C180912" @default.
- NCIT_C180912 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C180912 NCIT_P108 "Anti-SARS-CoV-2 Monoclonal Antibodies C135-LS/C144-LS" @default.
- NCIT_C180912 NCIT_P208 "CL1663650" @default.
- NCIT_C180912 NCIT_R124 NCIT_C17710 @default.
- NCIT_C180912 NCIT_R124 NCIT_C17828 @default.
- NCIT_C180912 NCIT_R124 NCIT_C18219 @default.
- NCIT_C180912 NCIT_R124 NCIT_C19986 @default.
- NCIT_C180912 NCIT_R124 NCIT_C40474 @default.
- NCIT_C180912 normalizedInformationContent "100" @default.
- NCIT_C180912 referenceCount "1" @default.
- NCIT_C180912 hasExactSynonym "Anti-SARS-CoV-2 Monoclonal Antibodies BMS-986413 + BMS-986414" @default.
- NCIT_C180912 hasExactSynonym "Anti-SARS-CoV-2 Monoclonal Antibodies BMS-986413/BMS-986414" @default.
- NCIT_C180912 hasExactSynonym "Anti-SARS-CoV-2 Monoclonal Antibodies C135-LS + C144-LS" @default.
- NCIT_C180912 hasExactSynonym "Anti-SARS-CoV-2 Monoclonal Antibodies C135-LS/C144-LS" @default.
- NCIT_C180912 hasExactSynonym "BMS-986413 + BMS-986414" @default.
- NCIT_C180912 hasExactSynonym "BMS-986413/BMS-986414" @default.
- NCIT_C180912 hasExactSynonym "C135-LS + C144-LS" @default.
- NCIT_C180912 hasExactSynonym "C135-LS Plus C144-LS" @default.
- NCIT_C180912 hasExactSynonym "C135-LS and C144-LS" @default.
- NCIT_C180912 hasExactSynonym "C135-LS/C144-LS" @default.
- NCIT_C180912 inSubset NCIT_C173381 @default.
- NCIT_C180912 inSubset NCIT_C173383 @default.
- NCIT_C180912 type Class @default.
- NCIT_C180912 isDefinedBy ncit.owl @default.
- NCIT_C180912 label "Anti-SARS-CoV-2 Monoclonal Antibodies C135-LS/C144-LS" @default.
- NCIT_C180912 subClassOf NCIT_C173741 @default.
- NCIT_C180912 subClassOf NCIT_C180912 @default.
- NCIT_C180912 subClassOf NCIT_C1908 @default.
- NCIT_C180912 subClassOf NCIT_C1909 @default.
- NCIT_C180912 subClassOf NCIT_C20401 @default.
- NCIT_C180912 subClassOf NCIT_C307 @default.
- NCIT_C180912 subClassOf NCIT_C308 @default.