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- NCIT_C181013 IAO_0000115 "A parenteral antibiotic preparation containing imipenem, cilastatin sodium and relebactam, with bactericidal activity. Imipenem, a broad spectrum beta-lactam carbapenem antibiotic, binds to and inactivates penicillin-binding proteins (PBP) on the inner membrane of the bacterial cell wall, thereby interfering with the cross-linkage of peptidoglycan chains critical for bacterial cell wall strength and rigidity. Cilastatin sodium, a renal dehydropeptidase inhibitor, reduces the breakdown of imipenem by renal dehydropeptidase. Relebactam, a beta-lactamase inhibitor, reduces the breakdown of imipenem by certain serine beta-lactamases among gram-negative bacteria. Imipenem is active against a wide range of gram-positive and gram-negative organisms, and the imipenem, cilastatin sodium and relebactam combination may be used to treat infections caused by resistant gram-negative bacteria." @default.
- NCIT_C181013 NCIT_NHC0 "C181013" @default.
- NCIT_C181013 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C181013 NCIT_P107 "Imipenem-Cilastatin-Relebactam" @default.
- NCIT_C181013 NCIT_P108 "Imipenem-Cilastatin-Relebactam" @default.
- NCIT_C181013 NCIT_P208 "CL1663614" @default.
- NCIT_C181013 NCIT_P322 "CTRP" @default.
- NCIT_C181013 NCIT_P399 "806257" @default.
- NCIT_C181013 normalizedInformationContent "100" @default.
- NCIT_C181013 referenceCount "1" @default.
- NCIT_C181013 hasExactSynonym "Imipenem-Cilastatin-Relebactam" @default.
- NCIT_C181013 hasExactSynonym "Imipenem/Cilastatin Sodium/Relebactam" @default.
- NCIT_C181013 hasExactSynonym "Recarbrio" @default.
- NCIT_C181013 inSubset NCIT_C116977 @default.
- NCIT_C181013 inSubset NCIT_C116978 @default.
- NCIT_C181013 inSubset NCIT_C176424 @default.
- NCIT_C181013 type Class @default.
- NCIT_C181013 isDefinedBy ncit.owl @default.
- NCIT_C181013 label "Imipenem-Cilastatin-Relebactam" @default.
- NCIT_C181013 subClassOf NCIT_C181013 @default.
- NCIT_C181013 subClassOf NCIT_C1908 @default.
- NCIT_C181013 subClassOf NCIT_C1909 @default.
- NCIT_C181013 subClassOf NCIT_C254 @default.
- NCIT_C181013 subClassOf NCIT_C258 @default.
- NCIT_C181013 subClassOf NCIT_C260 @default.