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- NCIT_C181014 IAO_0000115 "An orally bioavailable inhibitor of the enzyme cyclooxygenase-2 (COX-2), with potential analgesic, anti-inflammatory and antineoplastic activities. Upon oral administration, COX-2 inhibitor ECP-1014 inhibits COX-2, thereby inhibiting the conversion of arachidonic acid to prostaglandins, including prostaglandin E2 (PGE2). This may reduce pain and inflammation. The COX-2/PGE 2 pathway may also play an important role in tumor proliferation, angiogenesis, metastasis and immune suppression in the tumor microenvironment (TME). COX-2 is overexpressed in certain tumor cells." @default.
- NCIT_C181014 NCIT_A7 NCIT_C17984 @default.
- NCIT_C181014 NCIT_NHC0 "C181014" @default.
- NCIT_C181014 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C181014 NCIT_P108 "COX-2 Inhibitor ECP-1014" @default.
- NCIT_C181014 NCIT_P208 "CL1663615" @default.
- NCIT_C181014 NCIT_P322 "GDC" @default.
- NCIT_C181014 NCIT_P399 "805807" @default.
- NCIT_C181014 normalizedInformationContent "100" @default.
- NCIT_C181014 referenceCount "1" @default.
- NCIT_C181014 hasExactSynonym "COX-2 Inhibitor ECP-1014" @default.
- NCIT_C181014 hasExactSynonym "Cyclooxygenase-2 Inhibitor ECP-1014" @default.
- NCIT_C181014 hasExactSynonym "ECP 1014" @default.
- NCIT_C181014 hasExactSynonym "ECP-1014" @default.
- NCIT_C181014 hasExactSynonym "ECP1014" @default.
- NCIT_C181014 hasExactSynonym "GIBH-1014" @default.
- NCIT_C181014 inSubset NCIT_C128784 @default.
- NCIT_C181014 inSubset NCIT_C157711 @default.
- NCIT_C181014 inSubset NCIT_C157712 @default.
- NCIT_C181014 inSubset NCIT_C176424 @default.
- NCIT_C181014 type Class @default.
- NCIT_C181014 isDefinedBy ncit.owl @default.
- NCIT_C181014 label "COX-2 Inhibitor ECP-1014" @default.
- NCIT_C181014 subClassOf NCIT_C1323 @default.
- NCIT_C181014 subClassOf NCIT_C1742 @default.
- NCIT_C181014 subClassOf NCIT_C181014 @default.
- NCIT_C181014 subClassOf NCIT_C1908 @default.
- NCIT_C181014 subClassOf NCIT_C1909 @default.
- NCIT_C181014 subClassOf NCIT_C2198 @default.
- NCIT_C181014 subClassOf NCIT_C2356 @default.
- NCIT_C181014 subClassOf NCIT_C241 @default.
- NCIT_C181014 subClassOf NCIT_C257 @default.
- NCIT_C181014 subClassOf NCIT_C274 @default.
- NCIT_C181014 subClassOf NCIT_C471 @default.
- NCIT_C181014 subClassOf NCIT_C78272 @default.
- NCIT_C181014 subClassOf NCIT_C80509 @default.