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- NCIT_C181080 IAO_0000115 "An orally bioavailable inhibitor of specific mutated forms of platelet-derived growth factor receptor alpha (PDGFR alpha; PDGFRa) and mast/stem cell factor receptor c-Kit (SCFR; CD117), with potential antineoplastic activity. Upon oral administration, PDGFR alpha/KIT mutant-specific inhibitor NB003 specifically targets, binds to and inhibits specific mutant forms of PDGFRa and c-Kit. This results in the inhibition of PDGFRa- and c-Kit-mediated signal transduction pathways and the inhibition of proliferation in tumor cells that express these PDGFRa and c-Kit mutants. PDGFRa and c-Kit, protein tyrosine kinases, are upregulated or mutated in various tumor cell types; they play key roles in the regulation of cellular proliferation and resistance to chemotherapy." @default.
- NCIT_C181080 NCIT_A7 NCIT_C17328 @default.
- NCIT_C181080 NCIT_A7 NCIT_C30163 @default.
- NCIT_C181080 NCIT_NHC0 "C181080" @default.
- NCIT_C181080 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C181080 NCIT_P107 "PDGFR alpha/KIT Mutant-specific Inhibitor NB003" @default.
- NCIT_C181080 NCIT_P108 "PDGFR alpha/KIT Mutant-specific Inhibitor NB003" @default.
- NCIT_C181080 NCIT_P208 "CL1663704" @default.
- NCIT_C181080 NCIT_P322 "CTRP" @default.
- NCIT_C181080 NCIT_P322 "GDC" @default.
- NCIT_C181080 NCIT_P399 "806260" @default.
- NCIT_C181080 normalizedInformationContent "100" @default.
- NCIT_C181080 referenceCount "1" @default.
- NCIT_C181080 hasExactSynonym "NB 003" @default.
- NCIT_C181080 hasExactSynonym "NB-003" @default.
- NCIT_C181080 hasExactSynonym "NB003" @default.
- NCIT_C181080 hasExactSynonym "PDGFR alpha/KIT Mutant-specific Inhibitor NB003" @default.
- NCIT_C181080 inSubset NCIT_C116977 @default.
- NCIT_C181080 inSubset NCIT_C116978 @default.
- NCIT_C181080 inSubset NCIT_C128784 @default.
- NCIT_C181080 inSubset NCIT_C157711 @default.
- NCIT_C181080 inSubset NCIT_C157712 @default.
- NCIT_C181080 inSubset NCIT_C176424 @default.
- NCIT_C181080 type Class @default.
- NCIT_C181080 isDefinedBy ncit.owl @default.
- NCIT_C181080 label "PDGFR alpha/KIT Mutant-specific Inhibitor NB003" @default.
- NCIT_C181080 subClassOf NCIT_C129824 @default.
- NCIT_C181080 subClassOf NCIT_C129825 @default.
- NCIT_C181080 subClassOf NCIT_C1404 @default.
- NCIT_C181080 subClassOf NCIT_C159198 @default.
- NCIT_C181080 subClassOf NCIT_C159199 @default.
- NCIT_C181080 subClassOf NCIT_C163758 @default.
- NCIT_C181080 subClassOf NCIT_C163999 @default.
- NCIT_C181080 subClassOf NCIT_C164037 @default.
- NCIT_C181080 subClassOf NCIT_C181080 @default.
- NCIT_C181080 subClassOf NCIT_C1908 @default.
- NCIT_C181080 subClassOf NCIT_C1909 @default.
- NCIT_C181080 subClassOf NCIT_C1967 @default.
- NCIT_C181080 subClassOf NCIT_C2189 @default.
- NCIT_C181080 subClassOf NCIT_C274 @default.
- NCIT_C181080 subClassOf NCIT_C471 @default.