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- NCIT_C181677 IAO_0000115 "An engineered variant of the human cytokine interleukin-18 (IL-18; IL18), with potential immunostimulating and antineoplastic activities. Upon administration of engineered IL-18 variant ST-067, the IL-18 variant binds to and activates the IL-18 receptor. This promotes T-cell persistence and enhances the activity and maturation of natural killer (NK) cells, which potentiates the immune response against tumor cells. The IL-18 variant is engineered to preferably bind to the IL-18 receptor and not IL-18 binding protein (IL-18BP), which acts as a decoy receptor of IL-18 and prevents the activation of IL-18 receptor in the tumor microenvironment (TME)." @default.
- NCIT_C181677 NCIT_NHC0 "C181677" @default.
- NCIT_C181677 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C181677 NCIT_P107 "Engineered Interleukin-18 Variant ST-067" @default.
- NCIT_C181677 NCIT_P108 "Engineered Interleukin-18 Variant ST-067" @default.
- NCIT_C181677 NCIT_P208 "CL1664805" @default.
- NCIT_C181677 NCIT_P322 "CTRP" @default.
- NCIT_C181677 NCIT_P322 "GDC" @default.
- NCIT_C181677 NCIT_R125 NCIT_C17828 @default.
- NCIT_C181677 NCIT_R125 NCIT_C18081 @default.
- NCIT_C181677 NCIT_R125 NCIT_C20480 @default.
- NCIT_C181677 NCIT_R125 NCIT_C20751 @default.
- NCIT_C181677 normalizedInformationContent "100" @default.
- NCIT_C181677 referenceCount "1" @default.
- NCIT_C181677 hasExactSynonym "Engineered IL-18 Variant ST-067" @default.
- NCIT_C181677 hasExactSynonym "Engineered Interleukin-18 Variant ST-067" @default.
- NCIT_C181677 hasExactSynonym "ST 067" @default.
- NCIT_C181677 hasExactSynonym "ST-067" @default.
- NCIT_C181677 hasExactSynonym "ST067" @default.
- NCIT_C181677 inSubset NCIT_C116977 @default.
- NCIT_C181677 inSubset NCIT_C116978 @default.
- NCIT_C181677 inSubset NCIT_C128784 @default.
- NCIT_C181677 inSubset NCIT_C157711 @default.
- NCIT_C181677 inSubset NCIT_C157712 @default.
- NCIT_C181677 inSubset NCIT_C176424 @default.
- NCIT_C181677 type Class @default.
- NCIT_C181677 isDefinedBy ncit.owl @default.
- NCIT_C181677 label "Engineered Interleukin-18 Variant ST-067" @default.
- NCIT_C181677 subClassOf NCIT_C1283 @default.
- NCIT_C181677 subClassOf NCIT_C181677 @default.
- NCIT_C181677 subClassOf NCIT_C1908 @default.
- NCIT_C181677 subClassOf NCIT_C1909 @default.
- NCIT_C181677 subClassOf NCIT_C307 @default.
- NCIT_C181677 subClassOf NCIT_C308 @default.
- NCIT_C181677 subClassOf NCIT_C593 @default.