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- NCIT_C181747 IAO_0000115 "An off-the-shelf (OTS) preparation composed of human allogeneic T-cells and containing primarily stem cell memory T-cells (Tscm) that are transfected by electroporation with a proprietary transposon-based DNA plasmid vector (PiggyBac; PB) encoding for an undisclosed drug selection gene encoding for a selectable marker to generate close to 100% CAR-based product, a caspase-based safety switch to reduce or eliminate the product in vivo if needed, and a B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17)-specific single domain variable heavy chain (VH) chimeric antigen receptor (CAR) (VCAR), with potential immunostimulating and antineoplastic activities. The CAR T-cells are also site specifically gene-edited with Cas-CLOVER (CC) to eliminate surface expression of both T-cell receptor (TCR) and beta-2 microglobulin (beta 2M) to decrease major histocompatibility complex (MHC) class I expression and further selected, by depletion of residual CD3-positive/TCR-positive cells, and expanded to yield Tscm enriched allogeneic transposed CAR-T cells. Upon administration, allogeneic anti-BCMA CAR T cells P-BCMA-ALLO1 specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a tumor-specific antigen and a member of the tumor necrosis factor receptor superfamily (TNFRSF) that binds to both a proliferation-inducing ligand (APRIL; TNFSF13) and B-cell activating factor (BAFF; TNFSF13B), plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and is overexpressed on malignant plasma cells." @default.
- NCIT_C181747 NCIT_A7 NCIT_C97848 @default.
- NCIT_C181747 NCIT_NHC0 "C181747" @default.
- NCIT_C181747 NCIT_P106 "Cell" @default.
- NCIT_C181747 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C181747 NCIT_P107 "Allogeneic Anti-BCMA CAR T Cells P-BCMA-ALLO1" @default.
- NCIT_C181747 NCIT_P108 "Allogeneic Anti-BCMA CAR T Cells P-BCMA-ALLO1" @default.
- NCIT_C181747 NCIT_P208 "CL1664652" @default.
- NCIT_C181747 NCIT_P322 "CTRP" @default.
- NCIT_C181747 NCIT_P322 "GDC" @default.
- NCIT_C181747 NCIT_P399 "805848" @default.
- NCIT_C181747 normalizedInformationContent "100" @default.
- NCIT_C181747 referenceCount "1" @default.
- NCIT_C181747 hasExactSynonym "Allogeneic Anti-BCMA CAR T Cells P-BCMA-ALLO1" @default.
- NCIT_C181747 hasExactSynonym "Allogeneic Anti-BCMA-CAR-expressing Tscm P-BCMA-ALLO1" @default.
- NCIT_C181747 hasExactSynonym "Allogeneic Tscm-rich Anti-BCMA CAR T Cells P-BCMA-ALLO1" @default.
- NCIT_C181747 hasExactSynonym "P-BCMA-ALLO 1" @default.
- NCIT_C181747 hasExactSynonym "P-BCMA-ALLO-1" @default.
- NCIT_C181747 hasExactSynonym "P-BCMA-ALLO1" @default.
- NCIT_C181747 inSubset NCIT_C116977 @default.
- NCIT_C181747 inSubset NCIT_C116978 @default.
- NCIT_C181747 inSubset NCIT_C128784 @default.
- NCIT_C181747 inSubset NCIT_C157711 @default.
- NCIT_C181747 inSubset NCIT_C157712 @default.
- NCIT_C181747 inSubset NCIT_C176424 @default.
- NCIT_C181747 type Class @default.
- NCIT_C181747 isDefinedBy ncit.owl @default.
- NCIT_C181747 label "Allogeneic Anti-BCMA CAR T Cells P-BCMA-ALLO1" @default.
- NCIT_C181747 subClassOf NCIT_C129820 @default.
- NCIT_C181747 subClassOf NCIT_C129821 @default.
- NCIT_C181747 subClassOf NCIT_C129826 @default.
- NCIT_C181747 subClassOf NCIT_C137999 @default.
- NCIT_C181747 subClassOf NCIT_C142078 @default.
- NCIT_C181747 subClassOf NCIT_C154231 @default.
- NCIT_C181747 subClassOf NCIT_C176023 @default.
- NCIT_C181747 subClassOf NCIT_C181747 @default.
- NCIT_C181747 subClassOf NCIT_C1908 @default.
- NCIT_C181747 subClassOf NCIT_C1909 @default.
- NCIT_C181747 subClassOf NCIT_C1962 @default.
- NCIT_C181747 subClassOf NCIT_C200765 @default.
- NCIT_C181747 subClassOf NCIT_C274 @default.
- NCIT_C181747 subClassOf NCIT_C28676 @default.
- NCIT_C181747 subClassOf NCIT_C307 @default.
- NCIT_C181747 subClassOf NCIT_C308 @default.