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- NCIT_C181768 IAO_0000115 "A recombinant, humanized, agonistic monoclonal antibody targeting the B-cell surface antigen CD40, with potential immunostimulatory and antineoplastic activities. Upon administration, anti-CD40 agonist monoclonal antibody MIL97 targets and binds to CD40 on a variety of immune cell types. This induces CD40-dependent signaling pathways, triggers the proliferation and activation of antigen-presenting cells (APCs) and activates T-cells. This results in an enhanced cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells. CD40, a cell surface receptor and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on various immune cells, such as dendritic cells (DCs), macrophages and B-cells, and plays a key role in the activation of the immune system." @default.
- NCIT_C181768 NCIT_A7 NCIT_C17281 @default.
- NCIT_C181768 NCIT_NHC0 "C181768" @default.
- NCIT_C181768 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C181768 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C181768 NCIT_P108 "Anti-CD40 Agonist Monoclonal Antibody MIL97" @default.
- NCIT_C181768 NCIT_P208 "CL1664646" @default.
- NCIT_C181768 NCIT_P322 "GDC" @default.
- NCIT_C181768 NCIT_P399 "805862" @default.
- NCIT_C181768 NCIT_R124 NCIT_C17710 @default.
- NCIT_C181768 NCIT_R124 NCIT_C17828 @default.
- NCIT_C181768 NCIT_R124 NCIT_C18219 @default.
- NCIT_C181768 NCIT_R124 NCIT_C19986 @default.
- NCIT_C181768 NCIT_R124 NCIT_C40474 @default.
- NCIT_C181768 normalizedInformationContent "100" @default.
- NCIT_C181768 referenceCount "1" @default.
- NCIT_C181768 hasExactSynonym "Anti-CD40 Agonist Antibody 2141-V11" @default.
- NCIT_C181768 hasExactSynonym "Anti-CD40 Agonist Monoclonal Antibody MIL97" @default.
- NCIT_C181768 hasExactSynonym "MIL 97" @default.
- NCIT_C181768 hasExactSynonym "MIL-97" @default.
- NCIT_C181768 hasExactSynonym "MIL97" @default.
- NCIT_C181768 inSubset NCIT_C128784 @default.
- NCIT_C181768 inSubset NCIT_C157711 @default.
- NCIT_C181768 inSubset NCIT_C157712 @default.
- NCIT_C181768 inSubset NCIT_C176424 @default.
- NCIT_C181768 type Class @default.
- NCIT_C181768 isDefinedBy ncit.owl @default.
- NCIT_C181768 label "Anti-CD40 Agonist Monoclonal Antibody MIL97" @default.
- NCIT_C181768 subClassOf NCIT_C129820 @default.
- NCIT_C181768 subClassOf NCIT_C133877 @default.
- NCIT_C181768 subClassOf NCIT_C181768 @default.
- NCIT_C181768 subClassOf NCIT_C1908 @default.
- NCIT_C181768 subClassOf NCIT_C1909 @default.
- NCIT_C181768 subClassOf NCIT_C191767 @default.
- NCIT_C181768 subClassOf NCIT_C20401 @default.
- NCIT_C181768 subClassOf NCIT_C274 @default.
- NCIT_C181768 subClassOf NCIT_C307 @default.
- NCIT_C181768 subClassOf NCIT_C308 @default.