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- NCIT_C181776 IAO_0000115 "An orally bioavailable inhibitor of Bruton's tyrosine kinase (BTK), with potential antineoplastic activity. Upon oral administration, zebutinib targets, binds to and inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways. This leads to an inhibition of the growth of malignant B-cells that overexpress BTK. BTK, a member of the src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed in B-cell malignancies; it plays an important role in B-lymphocyte development, activation, signaling, proliferation and survival." @default.
- NCIT_C181776 NCIT_A7 NCIT_C75017 @default.
- NCIT_C181776 NCIT_NHC0 "C181776" @default.
- NCIT_C181776 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C181776 NCIT_P108 "Zebutinib" @default.
- NCIT_C181776 NCIT_P208 "CL1664641" @default.
- NCIT_C181776 NCIT_P322 "GDC" @default.
- NCIT_C181776 NCIT_P399 "806023" @default.
- NCIT_C181776 normalizedInformationContent "100" @default.
- NCIT_C181776 referenceCount "1" @default.
- NCIT_C181776 hasExactSynonym "Baiyueze" @default.
- NCIT_C181776 hasExactSynonym "Zebutinib" @default.
- NCIT_C181776 inSubset NCIT_C128784 @default.
- NCIT_C181776 inSubset NCIT_C157711 @default.
- NCIT_C181776 inSubset NCIT_C157712 @default.
- NCIT_C181776 inSubset NCIT_C176424 @default.
- NCIT_C181776 type Class @default.
- NCIT_C181776 isDefinedBy ncit.owl @default.
- NCIT_C181776 label "Zebutinib" @default.
- NCIT_C181776 subClassOf NCIT_C124801 @default.
- NCIT_C181776 subClassOf NCIT_C129824 @default.
- NCIT_C181776 subClassOf NCIT_C129825 @default.
- NCIT_C181776 subClassOf NCIT_C1404 @default.
- NCIT_C181776 subClassOf NCIT_C163758 @default.
- NCIT_C181776 subClassOf NCIT_C163774 @default.
- NCIT_C181776 subClassOf NCIT_C181776 @default.
- NCIT_C181776 subClassOf NCIT_C1908 @default.
- NCIT_C181776 subClassOf NCIT_C1909 @default.
- NCIT_C181776 subClassOf NCIT_C1967 @default.
- NCIT_C181776 subClassOf NCIT_C2189 @default.
- NCIT_C181776 subClassOf NCIT_C274 @default.
- NCIT_C181776 subClassOf NCIT_C471 @default.