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- NCIT_C181804 IAO_0000115 "A preparation of off-the-shelf (OTS), allogeneic and ex vivo expanded natural killer cells (NKs) that are engineered to express membrane-bound IL-15 (mbIL15) and a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19 that is coupled to the co-stimulatory domain of OX40 (CD134), and to the zeta chain of the TCR/CD3 complex (CD3-zeta; CD3zeta), with potential immunomodulating and antineoplastic activities. Upon administration of allogeneic CD19-OX40-CD3zeta-CAR-mbIL-15-expressing NK cells NKX019, these cells specifically target and bind to tumor cells expressing CD19. This induces secretion of pro-inflammatory cytokines and results in the lysis of CD19-expressing tumor cells. IL-15 is a pro-survival cytokine that potentiates the immune response against tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies." @default.
- NCIT_C181804 NCIT_A7 NCIT_C38894 @default.
- NCIT_C181804 NCIT_NHC0 "C181804" @default.
- NCIT_C181804 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C181804 NCIT_P107 "Allogeneic CD19-OX40-CD3zeta-CAR-mbIL-15-expressing Natural Killer Cells NKX019" @default.
- NCIT_C181804 NCIT_P108 "Allogeneic CD19-OX40-CD3zeta-CAR-mbIL-15-expressing Natural Killer Cells NKX019" @default.
- NCIT_C181804 NCIT_P208 "CL1664712" @default.
- NCIT_C181804 NCIT_P322 "CTRP" @default.
- NCIT_C181804 NCIT_P322 "GDC" @default.
- NCIT_C181804 NCIT_P399 "806780" @default.
- NCIT_C181804 normalizedInformationContent "100" @default.
- NCIT_C181804 referenceCount "1" @default.
- NCIT_C181804 hasExactSynonym "Allogeneic Anti-CD-19 CAR NK Cells NKX019" @default.
- NCIT_C181804 hasExactSynonym "Allogeneic Anti-CD-19 CAR-NKs NKX019" @default.
- NCIT_C181804 hasExactSynonym "Allogeneic CD19-OX40-CD3zeta-CAR-mbIL-15-expressing NK Cells NKX019" @default.
- NCIT_C181804 hasExactSynonym "Allogeneic CD19-OX40-CD3zeta-CAR-mbIL-15-expressing NKs NKX019" @default.
- NCIT_C181804 hasExactSynonym "Allogeneic CD19-OX40-CD3zeta-CAR-mbIL-15-expressing Natural Killer Cells NKX019" @default.
- NCIT_C181804 hasExactSynonym "NKX 019" @default.
- NCIT_C181804 hasExactSynonym "NKX-019" @default.
- NCIT_C181804 hasExactSynonym "NKX019" @default.
- NCIT_C181804 inSubset NCIT_C116977 @default.
- NCIT_C181804 inSubset NCIT_C116978 @default.
- NCIT_C181804 inSubset NCIT_C128784 @default.
- NCIT_C181804 inSubset NCIT_C157711 @default.
- NCIT_C181804 inSubset NCIT_C157712 @default.
- NCIT_C181804 inSubset NCIT_C176424 @default.
- NCIT_C181804 type Class @default.
- NCIT_C181804 isDefinedBy ncit.owl @default.
- NCIT_C181804 label "Allogeneic CD19-OX40-CD3zeta-CAR-mbIL-15-expressing Natural Killer Cells NKX019" @default.
- NCIT_C181804 subClassOf NCIT_C129820 @default.
- NCIT_C181804 subClassOf NCIT_C129821 @default.
- NCIT_C181804 subClassOf NCIT_C129826 @default.
- NCIT_C181804 subClassOf NCIT_C142078 @default.
- NCIT_C181804 subClassOf NCIT_C181804 @default.
- NCIT_C181804 subClassOf NCIT_C1908 @default.
- NCIT_C181804 subClassOf NCIT_C1909 @default.
- NCIT_C181804 subClassOf NCIT_C201545 @default.
- NCIT_C181804 subClassOf NCIT_C274 @default.
- NCIT_C181804 subClassOf NCIT_C28676 @default.
- NCIT_C181804 subClassOf NCIT_C307 @default.
- NCIT_C181804 subClassOf NCIT_C308 @default.