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• NCIT_C18181 IAO_0000115 "Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (403 aa, ~47 kDa) is encoded by the human PTEN gene. This protein plays a role in signaling and as both a dual-specificity phosphoprotein phosphatase and a lipid phosphatase." @default.
• NCIT_C18181 NCIT_NHC0 "C18181" @default.
• NCIT_C18181 NCIT_P100 "601728" @default.
• NCIT_C18181 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
• NCIT_C18181 NCIT_P106 "Enzyme" @default.
• NCIT_C18181 NCIT_P107 "PTEN" @default.
• NCIT_C18181 NCIT_P108 "Phosphatidylinositol 3,4,5-Trisphosphate 3-Phosphatase and Dual-Specificity Protein Phosphatase PTEN" @default.
• NCIT_C18181 NCIT_P207 "C1430988" @default.
• NCIT_C18181 NCIT_P322 "CTRP" @default.
• NCIT_C18181 NCIT_P325 "A protein that helps control many cell functions, including cell division and cell death. Mutations (changes) in the gene that makes PTEN are found in many types of cancer and other diseases. It is a type of tumor suppressor protein." @default.
• NCIT_C18181 NCIT_P366 "PTEN_Tyrosine_Phosphatase" @default.
• NCIT_C18181 NCIT_P93 "P60484" @default.
• NCIT_C18181 NCIT_P98 "PTEN contains a tyrosine phosphatase domain and a region of homology to auxilin and tensin (which interacts with actin). PTEN inhibits insulin-induced IRS1 phosphorylation and IRS1/GRB2/SOS complex formation and influences the PI3 kinase/AKT pathway in FAS-induced apoptosis. PTEN blocks cell cycle progression in G1 through negative regulation of PI3 kinase/AKT signaling to cyclin-dependent kinase inhibitor p27(KIP1), increasing p27, decreasing cyclin D1, and inhibiting AKT phosphorylation." @default.
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• NCIT_C18181 NCIT_R54 NCIT_C26070 @default.
• NCIT_C18181 normalizedInformationContent "86.239998175184226" @default.
• NCIT_C18181 referenceCount "8" @default.
• NCIT_C18181 hasExactSynonym "EC 3.1.3.16" @default.
• NCIT_C18181 hasExactSynonym "EC 3.1.3.48" @default.
• NCIT_C18181 hasExactSynonym "EC 3.1.3.67" @default.
• NCIT_C18181 hasExactSynonym "Mitochondrial PTENalpha" @default.
• NCIT_C18181 hasExactSynonym "Mitochondrial Phosphatase and Tensin Protein Alpha" @default.
• NCIT_C18181 hasExactSynonym "Mutated in Multiple Advanced Cancers 1" @default.
• NCIT_C18181 hasExactSynonym "PTEN Tyrosine Phosphatase" @default.
• NCIT_C18181 hasExactSynonym "PTEN tyrosine phosphatase" @default.
• NCIT_C18181 hasExactSynonym "PTEN" @default.
• NCIT_C18181 hasExactSynonym "Phosphatase and Tensin Homolog" @default.
• NCIT_C18181 hasExactSynonym "Phosphatase and Tensin-Like Protein" @default.
• NCIT_C18181 hasExactSynonym "Phosphatidylinositol 3,4,5-Trisphosphate 3-Phosphatase and Dual-Specificity Protein Phosphatase PTEN" @default.
• NCIT_C18181 hasExactSynonym "Phosphatidylinositol-3,4,5-Trisphosphate 3-Phosphatase and Dual-Specificity Protein Phosphatase PTEN" @default.
• NCIT_C18181 inSubset NCIT_C116977 @default.
• NCIT_C18181 inSubset NCIT_C142799 @default.
• NCIT_C18181 inSubset NCIT_C142800 @default.
• NCIT_C18181 type Class @default.

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