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- NCIT_C182002 IAO_0000115 "A preparation of human T-lymphocytes genetically engineered to express an anti-epidermal growth factor receptor (EGFR) chimeric antigen receptor (CAR) gene and gene-edited with the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nuclease complex to disrupt expression of transforming growth factor-beta receptor II (TGFbRII), with potential immunostimulatory and antineoplastic activities. Upon administration, the CRISPR-Cas9 engineered TGFbRII-deleted anti-EGFR CAR T-cells target and bind to the EGFR antigen on tumor cell surfaces; subsequently, EGFR-expressing tumor cells may be lysed. EGFR, overexpressed by a variety of cancer cell types, plays a key role in tumor cell proliferation, tumor angiogenesis and radio- and chemoresistance. By knocking out the expression of TGFbRII, the immunosuppressive cytokine TGF-beta is unable to bind to the T-cells and prevent the activation of the T-cells. TGF-beta contributes to the immunosuppressive nature of the tumor microenvironment (TME), and plays a key role in promoting tumor initiation, metastasis, and suppressing anti-tumor immunity." @default.
- NCIT_C182002 NCIT_A7 NCIT_C17068 @default.
- NCIT_C182002 NCIT_NHC0 "C182002" @default.
- NCIT_C182002 NCIT_P106 "Cell" @default.
- NCIT_C182002 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C182002 NCIT_P108 "CRISPR-Cas9 Engineered TGFbRII-deleted Anti-EGFR CAR T-cells" @default.
- NCIT_C182002 NCIT_P208 "CL1664827" @default.
- NCIT_C182002 NCIT_P399 "806121" @default.
- NCIT_C182002 normalizedInformationContent "100" @default.
- NCIT_C182002 referenceCount "1" @default.
- NCIT_C182002 hasExactSynonym "CRISPR-Cas9 Engineered TGFbRII-deleted Anti-EGFR CAR T-cells" @default.
- NCIT_C182002 hasExactSynonym "TGFbR-KO CAR-EGFR T Cells" @default.
- NCIT_C182002 hasExactSynonym "TGFbeta Receptor II-Knockout EGFR CAR T Cells" @default.
- NCIT_C182002 inSubset NCIT_C128784 @default.
- NCIT_C182002 inSubset NCIT_C176424 @default.
- NCIT_C182002 type Class @default.
- NCIT_C182002 isDefinedBy ncit.owl @default.
- NCIT_C182002 label "CRISPR-Cas9 Engineered TGFbRII-deleted Anti-EGFR CAR T-cells" @default.
- NCIT_C182002 subClassOf NCIT_C129820 @default.
- NCIT_C182002 subClassOf NCIT_C129821 @default.
- NCIT_C182002 subClassOf NCIT_C129826 @default.
- NCIT_C182002 subClassOf NCIT_C137999 @default.
- NCIT_C182002 subClassOf NCIT_C142078 @default.
- NCIT_C182002 subClassOf NCIT_C154231 @default.
- NCIT_C182002 subClassOf NCIT_C182002 @default.
- NCIT_C182002 subClassOf NCIT_C1908 @default.
- NCIT_C182002 subClassOf NCIT_C1909 @default.
- NCIT_C182002 subClassOf NCIT_C1962 @default.
- NCIT_C182002 subClassOf NCIT_C201175 @default.
- NCIT_C182002 subClassOf NCIT_C274 @default.
- NCIT_C182002 subClassOf NCIT_C307 @default.
- NCIT_C182002 subClassOf NCIT_C308 @default.