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- NCIT_C182003 IAO_0000115 "An orally bioavailable and selective inhibitor of DNA polymerase (pol) theta, with potential chemosensitizing and antineoplastic activities. Upon oral administration, Pol theta inhibitor ART4215 targets, binds to and inhibits the activity of pol theta. This prevents pol theta-mediated repair of damaged DNA and may have a synergistic effect if administered in combination with agents that cause DNA damage. Pol theta plays a key role in DNA synthesis and repair." @default.
- NCIT_C182003 NCIT_A7 NCIT_C131803 @default.
- NCIT_C182003 NCIT_NHC0 "C182003" @default.
- NCIT_C182003 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C182003 NCIT_P107 "Pol Theta Inhibitor ART4215" @default.
- NCIT_C182003 NCIT_P108 "Pol Theta Inhibitor ART4215" @default.
- NCIT_C182003 NCIT_P208 "CL1664828" @default.
- NCIT_C182003 NCIT_P322 "CTRP" @default.
- NCIT_C182003 NCIT_P322 "GDC" @default.
- NCIT_C182003 NCIT_P399 "806122" @default.
- NCIT_C182003 normalizedInformationContent "100" @default.
- NCIT_C182003 referenceCount "1" @default.
- NCIT_C182003 hasExactSynonym "ART 4215" @default.
- NCIT_C182003 hasExactSynonym "ART-4215" @default.
- NCIT_C182003 hasExactSynonym "ART4215" @default.
- NCIT_C182003 hasExactSynonym "DNA Polymerase Theta Inhibitor ART4215" @default.
- NCIT_C182003 hasExactSynonym "Pol Theta Inhibitor ART4215" @default.
- NCIT_C182003 inSubset NCIT_C116977 @default.
- NCIT_C182003 inSubset NCIT_C116978 @default.
- NCIT_C182003 inSubset NCIT_C128784 @default.
- NCIT_C182003 inSubset NCIT_C157711 @default.
- NCIT_C182003 inSubset NCIT_C157712 @default.
- NCIT_C182003 inSubset NCIT_C176424 @default.
- NCIT_C182003 type Class @default.
- NCIT_C182003 isDefinedBy ncit.owl @default.
- NCIT_C182003 label "Pol Theta Inhibitor ART4215" @default.
- NCIT_C182003 subClassOf NCIT_C182003 @default.
- NCIT_C182003 subClassOf NCIT_C1908 @default.
- NCIT_C182003 subClassOf NCIT_C1909 @default.
- NCIT_C182003 subClassOf NCIT_C29575 @default.
- NCIT_C182003 subClassOf NCIT_C471 @default.