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- NCIT_C182004 IAO_0000115 "An antibody-drug conjugate (ADC) consisting of REGN5093, a biparatopic monoclonal antibody that targets two different epitopes of the human tumor-associated antigen (TAA) MET (c-MET; hepatocyte growth factor receptor; HGFR), and conjugated, via a protease cleavable linker, to the cytotoxic maytansine derivative M24, with potential antineoplastic activity. Upon administration of anti-MET x MET ADC REGN5093-M114, the REGN5093 moiety targets and binds to two different, non-overlapping epitopes on MET expressed on the tumor cell surface. After antibody-antigen interaction followed by internalization and protease cleavage, the maytansine M24 moiety binds to tubulin, inhibits microtubule assembly, and induces microtubule disassembly. This leads to a disruption of mitosis and the inhibition of cell proliferation in cancer cells expressing MET. MET, a receptor tyrosine kinase, is overexpressed on the cell surfaces of various solid tumor cell types where it is involved in epithelial-mesenchymal transition; it plays a key role in cancer cell growth, survival, angiogenesis, invasion, and metastasis." @default.
- NCIT_C182004 NCIT_A7 NCIT_C18186 @default.
- NCIT_C182004 NCIT_NHC0 "C182004" @default.
- NCIT_C182004 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C182004 NCIT_P108 "Anti-MET x MET Antibody Drug Conjugate REGN5093-M114" @default.
- NCIT_C182004 NCIT_P208 "CL1664825" @default.
- NCIT_C182004 NCIT_P322 "GDC" @default.
- NCIT_C182004 NCIT_P399 "806123" @default.
- NCIT_C182004 normalizedInformationContent "100" @default.
- NCIT_C182004 referenceCount "1" @default.
- NCIT_C182004 hasExactSynonym "ADC REGN5093-M114" @default.
- NCIT_C182004 hasExactSynonym "Anti-MET ADC REGN5093-M114" @default.
- NCIT_C182004 hasExactSynonym "Anti-MET Antibody-drug Conjugate REGN5093-M114" @default.
- NCIT_C182004 hasExactSynonym "Anti-MET x MET ADC REGN5093-M114" @default.
- NCIT_C182004 hasExactSynonym "Anti-MET x MET Antibody Drug Conjugate REGN5093-M114" @default.
- NCIT_C182004 hasExactSynonym "Antibody-drug Conjugate REGN5093-M114" @default.
- NCIT_C182004 hasExactSynonym "MET x MET ADC REGN5093-M114" @default.
- NCIT_C182004 hasExactSynonym "REGN5093-M 114" @default.
- NCIT_C182004 hasExactSynonym "REGN5093-M-114" @default.
- NCIT_C182004 hasExactSynonym "REGN5093-M114" @default.
- NCIT_C182004 inSubset NCIT_C128784 @default.
- NCIT_C182004 inSubset NCIT_C157711 @default.
- NCIT_C182004 inSubset NCIT_C157712 @default.
- NCIT_C182004 inSubset NCIT_C176424 @default.
- NCIT_C182004 type Class @default.
- NCIT_C182004 isDefinedBy ncit.owl @default.
- NCIT_C182004 label "Anti-MET x MET Antibody Drug Conjugate REGN5093-M114" @default.
- NCIT_C182004 subClassOf NCIT_C129821 @default.
- NCIT_C182004 subClassOf NCIT_C129823 @default.
- NCIT_C182004 subClassOf NCIT_C1512 @default.
- NCIT_C182004 subClassOf NCIT_C163758 @default.
- NCIT_C182004 subClassOf NCIT_C164000 @default.
- NCIT_C182004 subClassOf NCIT_C182004 @default.
- NCIT_C182004 subClassOf NCIT_C1908 @default.
- NCIT_C182004 subClassOf NCIT_C1909 @default.
- NCIT_C182004 subClassOf NCIT_C201552 @default.
- NCIT_C182004 subClassOf NCIT_C274 @default.
- NCIT_C182004 subClassOf NCIT_C307 @default.
- NCIT_C182004 subClassOf NCIT_C308 @default.