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- NCIT_C182007 IAO_0000115 "An orally bioavailable, small molecule inhibitor of menin, with potential antineoplastic activity. Upon oral administration, menin inhibitor DSP-5336 targets and binds to the nuclear protein menin, thereby preventing the interaction between the two proteins menin and menin-mixed lineage leukemia (MLL; myeloid/lymphoid leukemia; KMT2A) and the formation of the menin-MLL complex. This reduces the expression of downstream target genes and results in an inhibition of the proliferation of MLL-rearranged leukemic cells. The menin-MLL complex plays a key role in the survival, growth, transformation and proliferation of certain kinds of leukemia cells." @default.
- NCIT_C182007 NCIT_A7 NCIT_C18051 @default.
- NCIT_C182007 NCIT_NHC0 "C182007" @default.
- NCIT_C182007 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C182007 NCIT_P107 "Menin Inhibitor DSP-5336" @default.
- NCIT_C182007 NCIT_P108 "Menin Inhibitor DSP-5336" @default.
- NCIT_C182007 NCIT_P208 "CL1664816" @default.
- NCIT_C182007 NCIT_P322 "CTRP" @default.
- NCIT_C182007 NCIT_P322 "GDC" @default.
- NCIT_C182007 NCIT_P399 "806137" @default.
- NCIT_C182007 normalizedInformationContent "100" @default.
- NCIT_C182007 referenceCount "1" @default.
- NCIT_C182007 hasExactSynonym "DSP 5336" @default.
- NCIT_C182007 hasExactSynonym "DSP-5336" @default.
- NCIT_C182007 hasExactSynonym "DSP5336" @default.
- NCIT_C182007 hasExactSynonym "Menin Inhibitor DSP-5336" @default.
- NCIT_C182007 hasExactSynonym "Menin-MLL Interaction Inhibitor DSP-5336" @default.
- NCIT_C182007 inSubset NCIT_C116977 @default.
- NCIT_C182007 inSubset NCIT_C116978 @default.
- NCIT_C182007 inSubset NCIT_C128784 @default.
- NCIT_C182007 inSubset NCIT_C157711 @default.
- NCIT_C182007 inSubset NCIT_C157712 @default.
- NCIT_C182007 inSubset NCIT_C176424 @default.
- NCIT_C182007 type Class @default.
- NCIT_C182007 isDefinedBy ncit.owl @default.
- NCIT_C182007 label "Menin Inhibitor DSP-5336" @default.
- NCIT_C182007 subClassOf NCIT_C182007 @default.
- NCIT_C182007 subClassOf NCIT_C185877 @default.
- NCIT_C182007 subClassOf NCIT_C1908 @default.
- NCIT_C182007 subClassOf NCIT_C1909 @default.
- NCIT_C182007 subClassOf NCIT_C2189 @default.
- NCIT_C182007 subClassOf NCIT_C274 @default.