Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C182011> ?p ?o ?g. }
Showing items 1 to 38 of
38
with 100 items per page.
- NCIT_C182011 IAO_0000115 "An orally bioavailable, small molecule, dual inhibitor of ataxia telangiectasia mutated kinase (ATM) and DNA-dependent protein kinase (DNA-PK), with potential radio-sensitizing and antineoplastic activities. Upon oral administration, ATM kinase/DNA-PK inhibitor XRD-0394 selectively targets, binds to and inhibits the activity of ATM and DNA-PK. This inhibits ATM-mediated signaling, which may prevent DNA damage checkpoint activation, disrupt DNA damage repair and induce tumor cell apoptosis. By disrupting DNA damage repair, this agent may sensitize tumor cells to radiotherapy and increase its anti-tumor activity. In addition, by inhibiting the activity of DNA-PK, this agent interferes with the non-homologous end joining (NHEJ) process which may prevent the repair of DNA double strand breaks (DSBs) caused by ionizing radiation. This may also increase radiotherapy cytotoxicity leading to enhanced tumor cell death. ATM, a serine/threonine protein kinase upregulated in a variety of cancer cell types, is activated in response to DNA damage and plays a key role in DNA-strand repair. DNA-PK plays a key role in the NHEJ pathway and DSB repair. The enhanced ability of tumor cells to repair DNA damage plays a major role in the resistance of tumor cells to radiotherapy." @default.
- NCIT_C182011 NCIT_A7 NCIT_C17924 @default.
- NCIT_C182011 NCIT_A7 NCIT_C21483 @default.
- NCIT_C182011 NCIT_NHC0 "C182011" @default.
- NCIT_C182011 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C182011 NCIT_P107 "ATM Kinase/DNA-PK Inhibitor XRD-0394" @default.
- NCIT_C182011 NCIT_P108 "ATM Kinase/DNA-PK Inhibitor XRD-0394" @default.
- NCIT_C182011 NCIT_P208 "CL1664820" @default.
- NCIT_C182011 NCIT_P322 "CTRP" @default.
- NCIT_C182011 NCIT_P322 "GDC" @default.
- NCIT_C182011 NCIT_P399 "810759" @default.
- NCIT_C182011 normalizedInformationContent "100" @default.
- NCIT_C182011 referenceCount "1" @default.
- NCIT_C182011 hasExactSynonym "ATM Kinase/DNA-PK Inhibitor XRD-0394" @default.
- NCIT_C182011 hasExactSynonym "Ataxia Telangiectasia Mutated Kinase/DNA-dependent Protein Kinase Inhibitor XRD-0394" @default.
- NCIT_C182011 hasExactSynonym "XRD 0394" @default.
- NCIT_C182011 hasExactSynonym "XRD-0394" @default.
- NCIT_C182011 hasExactSynonym "XRD0394" @default.
- NCIT_C182011 inSubset NCIT_C116977 @default.
- NCIT_C182011 inSubset NCIT_C116978 @default.
- NCIT_C182011 inSubset NCIT_C128784 @default.
- NCIT_C182011 inSubset NCIT_C157711 @default.
- NCIT_C182011 inSubset NCIT_C157712 @default.
- NCIT_C182011 inSubset NCIT_C176424 @default.
- NCIT_C182011 type Class @default.
- NCIT_C182011 isDefinedBy ncit.owl @default.
- NCIT_C182011 label "ATM Kinase/DNA-PK Inhibitor XRD-0394" @default.
- NCIT_C182011 subClassOf NCIT_C129824 @default.
- NCIT_C182011 subClassOf NCIT_C129825 @default.
- NCIT_C182011 subClassOf NCIT_C1404 @default.
- NCIT_C182011 subClassOf NCIT_C182011 @default.
- NCIT_C182011 subClassOf NCIT_C1908 @default.
- NCIT_C182011 subClassOf NCIT_C1909 @default.
- NCIT_C182011 subClassOf NCIT_C192218 @default.
- NCIT_C182011 subClassOf NCIT_C2189 @default.
- NCIT_C182011 subClassOf NCIT_C274 @default.
- NCIT_C182011 subClassOf NCIT_C471 @default.
- NCIT_C182011 subClassOf NCIT_C61074 @default.