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- NCIT_C182066 IAO_0000115 "A preparation of allogeneic, transcription activator-like effector nuclease (TALEN)-engineered, gene-edited T-lymphocytes that have been transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) targeting the human tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and engineered to express a constitutively active chimeric cytokine receptor (CACCR), with potential immunostimulating and antineoplastic activities. Using TALEN technology, the T-cell receptor (TCR) alpha chain (TRAC) and CD52 genes are inactivated. Upon administration, the allogeneic anti-BCMA CAR T Cells ALLO-605 specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). BCMA is found on the surfaces of plasma cells, is overexpressed on malignant plasma cells and plays a key role in plasma cell proliferation and survival. Inactivation of the CD52 gene makes the modified donor T-cells resistant to an anti-CD52 monoclonal antibody treatment, that is used during lymphodepletion. The knockout of TRAC eliminates TCR expression and is intended to abrogate the potential induction of graft-versus-host disease (GvHD) by the donor T-cells. The expression of CACCR allows for intracellular cytokine activation signaling, which may enhance expansion and persistence of the CAR T cells, thereby improving long-term anti-tumor activity. In addition, the incorporated CD20-based off-switch of ALLO-605 permits selective depletion of the ALLO-605 cells when the anti-CD20 monoclonal antibody rituximab is administered. ALLO-605 can also be inactivated with dasatinib." @default.
- NCIT_C182066 NCIT_A7 NCIT_C97848 @default.
- NCIT_C182066 NCIT_NHC0 "C182066" @default.
- NCIT_C182066 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C182066 NCIT_P107 "Allogeneic Anti-BCMA CAR T Cells ALLO-605" @default.
- NCIT_C182066 NCIT_P108 "Allogeneic Anti-BCMA CAR T Cells ALLO-605" @default.
- NCIT_C182066 NCIT_P208 "CL1770673" @default.
- NCIT_C182066 NCIT_P322 "CTRP" @default.
- NCIT_C182066 NCIT_P322 "GDC" @default.
- NCIT_C182066 NCIT_P399 "806178" @default.
- NCIT_C182066 normalizedInformationContent "100" @default.
- NCIT_C182066 referenceCount "1" @default.
- NCIT_C182066 hasExactSynonym "ALLO 605" @default.
- NCIT_C182066 hasExactSynonym "ALLO-605" @default.
- NCIT_C182066 hasExactSynonym "ALLO605" @default.
- NCIT_C182066 hasExactSynonym "Allogeneic Anti-BCMA CAR T Cells ALLO-605" @default.
- NCIT_C182066 hasExactSynonym "Allogeneic Anti-BCMA CAR-T Cells ALLO-605" @default.
- NCIT_C182066 hasExactSynonym "Allogeneic Anti-BCMA TRAC/CD52-edited CAR T Cells ALLO-605" @default.
- NCIT_C182066 hasExactSynonym "Allogeneic BCMA TurboCAR T Cells ALLO-605" @default.
- NCIT_C182066 inSubset NCIT_C116977 @default.
- NCIT_C182066 inSubset NCIT_C116978 @default.
- NCIT_C182066 inSubset NCIT_C128784 @default.
- NCIT_C182066 inSubset NCIT_C157711 @default.
- NCIT_C182066 inSubset NCIT_C157712 @default.
- NCIT_C182066 inSubset NCIT_C176424 @default.
- NCIT_C182066 type Class @default.
- NCIT_C182066 isDefinedBy ncit.owl @default.
- NCIT_C182066 label "Allogeneic Anti-BCMA CAR T Cells ALLO-605" @default.
- NCIT_C182066 subClassOf NCIT_C129820 @default.
- NCIT_C182066 subClassOf NCIT_C129821 @default.
- NCIT_C182066 subClassOf NCIT_C129826 @default.
- NCIT_C182066 subClassOf NCIT_C137999 @default.
- NCIT_C182066 subClassOf NCIT_C142078 @default.
- NCIT_C182066 subClassOf NCIT_C154231 @default.
- NCIT_C182066 subClassOf NCIT_C176023 @default.
- NCIT_C182066 subClassOf NCIT_C182066 @default.
- NCIT_C182066 subClassOf NCIT_C1908 @default.
- NCIT_C182066 subClassOf NCIT_C1909 @default.
- NCIT_C182066 subClassOf NCIT_C1962 @default.
- NCIT_C182066 subClassOf NCIT_C200765 @default.
- NCIT_C182066 subClassOf NCIT_C274 @default.
- NCIT_C182066 subClassOf NCIT_C28676 @default.
- NCIT_C182066 subClassOf NCIT_C307 @default.
- NCIT_C182066 subClassOf NCIT_C308 @default.