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- NCIT_C182073 IAO_0000115 "A bispecific antibody targeting the tumor-associated antigen (TAA) HLA-G histocompatibility antigen, class I, G (human leukocyte antigen G; HLA-G) and the CD3 antigen found on T-lymphocytes, with potential immune checkpoint inhibiting, immunomodulating and antineoplastic activities. Upon administration, the anti-HLA-G/CD3 bispecific antibody JNJ-78306358 targets and binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and HLA-G found on HLA-G-expressing tumor cells. This activates and redirects CTLs to HLA-G-expressing tumor cells, which results in the CTL-mediated cell death of HLA-G-expressing tumor cells. HLA-G, an immune checkpoint normally expressed at the maternal-fetal interface, is expressed across multiple tumor types and plays a key role in cancer immune evasion. It inhibits immune responses by binding to its inhibitory receptors on a variety of immune cells, such as natural killer cells (NKs), T- and B-lymphocytes, and dendritic cells (DCs)." @default.
- NCIT_C182073 NCIT_A7 NCIT_C104327 @default.
- NCIT_C182073 NCIT_NHC0 "C182073" @default.
- NCIT_C182073 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C182073 NCIT_P108 "Anti-HLA-G/CD3 Bispecific Antibody JNJ-78306358" @default.
- NCIT_C182073 NCIT_P208 "CL1770680" @default.
- NCIT_C182073 NCIT_P322 "GDC" @default.
- NCIT_C182073 NCIT_P399 "806156" @default.
- NCIT_C182073 NCIT_R124 NCIT_C17710 @default.
- NCIT_C182073 NCIT_R124 NCIT_C17828 @default.
- NCIT_C182073 NCIT_R124 NCIT_C18219 @default.
- NCIT_C182073 NCIT_R124 NCIT_C19986 @default.
- NCIT_C182073 NCIT_R124 NCIT_C40474 @default.
- NCIT_C182073 normalizedInformationContent "100" @default.
- NCIT_C182073 referenceCount "1" @default.
- NCIT_C182073 hasExactSynonym "Anti-HLA-G/CD3 Bispecific Antibody JNJ-78306358" @default.
- NCIT_C182073 hasExactSynonym "JNJ 78306358" @default.
- NCIT_C182073 hasExactSynonym "JNJ-78306358" @default.
- NCIT_C182073 hasExactSynonym "JNJ78306358" @default.
- NCIT_C182073 hasExactSynonym "T Cell Redirecting Bispecific Antibody JNJ-78306358" @default.
- NCIT_C182073 inSubset NCIT_C128784 @default.
- NCIT_C182073 inSubset NCIT_C157711 @default.
- NCIT_C182073 inSubset NCIT_C157712 @default.
- NCIT_C182073 inSubset NCIT_C176424 @default.
- NCIT_C182073 type Class @default.
- NCIT_C182073 isDefinedBy ncit.owl @default.
- NCIT_C182073 label "Anti-HLA-G/CD3 Bispecific Antibody JNJ-78306358" @default.
- NCIT_C182073 subClassOf NCIT_C112883 @default.
- NCIT_C182073 subClassOf NCIT_C129821 @default.
- NCIT_C182073 subClassOf NCIT_C129822 @default.
- NCIT_C182073 subClassOf NCIT_C141144 @default.
- NCIT_C182073 subClassOf NCIT_C143250 @default.
- NCIT_C182073 subClassOf NCIT_C1454 @default.
- NCIT_C182073 subClassOf NCIT_C182073 @default.
- NCIT_C182073 subClassOf NCIT_C1908 @default.
- NCIT_C182073 subClassOf NCIT_C1909 @default.
- NCIT_C182073 subClassOf NCIT_C201282 @default.
- NCIT_C182073 subClassOf NCIT_C20401 @default.
- NCIT_C182073 subClassOf NCIT_C274 @default.
- NCIT_C182073 subClassOf NCIT_C28227 @default.
- NCIT_C182073 subClassOf NCIT_C307 @default.
- NCIT_C182073 subClassOf NCIT_C308 @default.